Collection of 3 putative TBP human TFs out of 3 considered proteins
DBD Alignment (Click to open/enlarge)
| Description |
Structure |
| Ensembl ID | HGNC symbol | DBD Family | Is TF? | TF Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|---|---|---|---|
| TBP | TBP | Yes | Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro | Binds DNA in the pre-initiation complex | ||
| TBPL1 | TBP | Yes | Likely to be sequence specific TF | 2 Obligate heteromer | No motif | A more distant paralog of TBP and the only member of the TBP family that lacks the ability to bind the TATA box. (PMID: 21711503). In vitro, purified TLF-TFIIA binds directly to the NF1 promoter (PMID: 15767669), so likely an obligate heteromer. | ||
| TBPL2 | TBP | Yes | Inferred motif | 1 Monomer or homomultimer | High-throughput in vitro |