| TFAP2A |
AP-2 |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TFAP2B |
AP-2 |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TFAP2C |
AP-2 |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TFAP2D |
AP-2 |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Binds the same GCCTGAGGC sequence as the other AP-2s (PMID: 24789576) |
| TFAP2E |
AP-2 |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ARID1A |
ARID/BRIGHT |
No |
Unlikely to be sequence specific TF |
3 Low specificity DNA-binding protein |
No motif |
|
Non-specific DNA binder (PMID: 15170388). |
| ARID1B |
ARID/BRIGHT |
No |
Unlikely to be sequence specific TF |
3 Low specificity DNA-binding protein |
No motif |
|
Non-specific DNA binder (PMID: 15170388). |
| ARID3A |
ARID/BRIGHT |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| ARID3B |
ARID/BRIGHT |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ARID3C |
ARID/BRIGHT |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ARID4A |
ARID/BRIGHT |
No |
Unlikely to be sequence specific TF |
3 Low specificity DNA-binding protein |
No motif |
Has a putative AT-hook |
Binds DNA in a sequence non-specific manner (PMID: 15640446). |
| ARID4B |
ARID/BRIGHT |
No |
Unlikely to be sequence specific TF |
3 Low specificity DNA-binding protein |
No motif |
|
Binds DNA in a sequence non-specific manner (PMID: 15640446). |
| ARID5A |
ARID/BRIGHT |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| ARID5B |
ARID/BRIGHT |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
Has a putative AT-hook |
|
| JARID2 |
ARID/BRIGHT |
No |
Unlikely to be sequence specific TF |
3 Low specificity DNA-binding protein |
No motif |
|
Only ARID3 and ARID5 family members have sequence specificity (PMID: 15640446). |
| KDM5A |
ARID/BRIGHT |
No |
Unlikely to be sequence specific TF |
3 Low specificity DNA-binding protein |
No motif |
|
|
| KDM5B |
ARID/BRIGHT |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Binds GC-rich sequences such as CCGCCC (PMID: 18270511). |
| KDM5C |
ARID/BRIGHT |
No |
Unlikely to be sequence specific TF |
3 Low specificity DNA-binding protein |
No motif |
|
|
| KDM5D |
ARID/BRIGHT |
No |
Unlikely to be sequence specific TF |
3 Low specificity DNA-binding protein |
No motif |
|
Polycomb protein that is well-documented to bind histone marks (PMID: 27477906; PMID: 17351630; PMID: 17320160; PMID: 17320162). |
| ARID2 |
ARID/BRIGHT; RFX |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| AHCTF1 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| AHDC1 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| AKNA |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Binds AT-rich promoters of CD40 and CD40L and coordinates their expression (PMID: 11268217). |
| ASH1L |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| CBX2 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| DNTTIP1 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Has a putative AT-hook |
|
| DOT1L |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| GLYR1 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Has a putative AT-hook |
|
| HMGA1 |
AT hook |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| HMGA2 |
AT hook |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| PHF20 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| PHF21A |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Has a putative AT-hook |
|
| PRR12 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| SCML4 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| SETBP1 |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Orthologous protein from mouse (Setbp1) bind DNA sequence-specifically by PBM |
| SRCAP |
AT hook |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| C11orf95 |
BED ZF |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| FAM200B |
BED ZF |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| SGSM2 |
BED ZF |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBED1 |
BED ZF |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBED2 |
BED ZF |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Has a BED domain that should bind DNA, but lacks the dimerization domain (PMID: 20016685). |
| ZBED3 |
BED ZF |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBED4 |
BED ZF |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBED5 |
BED ZF |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBED6 |
BED ZF |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| ZBED8 |
BED ZF |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Despite its name, does not have a detectable BED ZF domain. |
| ZBED9 |
BED ZF |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| AHR |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| AHRR |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| ARNT |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| ARNT2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ARNTL |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ARNTL2 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
High-throughput in vitro |
|
ARNTL2 Forms heterodimers with CLOCK and NPAS2 (PMID:10864977 ). |
| ASCL1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ASCL2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ASCL3 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
High-throughput in vitro |
|
ASCL1 heterodimerizes with TCF3; TCF4 and TCF12 (PMID: 24835951). |
| ASCL4 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs |
| ASCL5 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs |
| ATOH1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ATOH7 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ATOH8 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| BHLHA15 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| BHLHA9 |
bHLH |
Yes |
Likely to be sequence specific TF |
2 Obligate heteromer |
No motif |
|
Protein heterodimerizes with TCF3; TCF4 and TCF12 (PMID: 25466284). |
| BHLHE22 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| BHLHE23 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| BHLHE40 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| BHLHE41 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CCDC169-SOHLH2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| CLOCK |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Can also bind as heterodimer with ARNTL. |
| EPAS1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| FERD3L |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| FIGLA |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HAND1 |
bHLH |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Obligate heteromer (PMID: 10611232). |
| HAND2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HELT |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Can form homodimers or heterodimers with HEY2 and HES5, suggesting also that the HELT homodimer is dependent of a additional Orange domain while the HEY2 heterodimer requires just the DBD (PMID: 14764602). |
| HES1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HES2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HES3 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HES4 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HES5 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HES6 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HES7 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Also forms heterodimers. |
| HEY1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HEY2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HEYL |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HIF1A |
bHLH |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Binds as obligate heteromer with ARNT (PMID: 9027737). |
| HIF3A |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
Binds DNA as a heterodimer with ARNT and ARNT2; reviewed in (PMID: 24099156). |
| ID1 |
bHLH |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination |
| ID2 |
bHLH |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination |
| ID3 |
bHLH |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination |
| ID4 |
bHLH |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination |
| LYL1 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
TAL1, TAL2 and LYL are very similar and have a basic region with a bulky tryptophan inserting into the cluster of the basic residues. Binds DNA as a heterodimer with TCF3 (PDB:2YPB and PDB:2YPA). |
| MAX |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MESP1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MESP2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MITF |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
Binds DNA both as homo- and heterodimers (PMID: 23207919). The structure 4ATI is a homodimer with DNA GTTAGCACATGACCCT. |
| MLX |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MLXIP |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
High-throughput in vitro |
|
|
| MLXIPL |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MNT |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Prefers to heterodimerize with MAX over homodimer formation (PMID: 9000049). |
| MSC |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MSGN1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MXD1 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822). |
| MXD3 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822). |
| MXD4 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822). |
| MXI1 |
bHLH |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Has a putative AT-hook |
Obligate heteromer (PMID: 8425219). |
| MYC |
bHLH |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
|
Functions as a heterodimer with MAX. |
| MYCL |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
Similar to MYC and thus likely to functions as a heterodimer with MAX. |
| MYCN |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MYF5 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| MYF6 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MYOD1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MYOG |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NCOA1 |
bHLH |
Yes |
Likely to be sequence specific TF |
2 Obligate heteromer |
No motif |
|
NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif. All are co-activators, collectively suggesting they might be obligate heteromers. |
| NCOA2 |
bHLH |
Yes |
Likely to be sequence specific TF |
2 Obligate heteromer |
No motif |
|
NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif. All are co-activators, collectively suggesting they might be obligate heteromers. |
| NCOA3 |
bHLH |
Yes |
Likely to be sequence specific TF |
2 Obligate heteromer |
No motif |
|
NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif. All are co-activators, collectively suggesting they might be obligate heteromers. |
| NEUROD1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NEUROD2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NEUROD4 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NEUROD6 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NEUROG1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NEUROG2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NEUROG3 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NHLH1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NHLH2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NPAS1 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
Likely obligate heteromer (PMID: 27782878). |
| NPAS2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NPAS3 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
Likely obligate heteromer (PMID: 9374395; PMID: 27782878). |
| NPAS4 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
High-throughput in vitro |
|
Likely dimerizes with ARNT2 (PMID:24263188). |
| OLIG1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| OLIG2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
OLIG2 can homodimerize and heterodimerize with OLIG1 and NGN2 (PMID:15655114; PMID: 21382552). |
| OLIG3 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| PTF1A |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SCX |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
SCX heterodimerizes with TCF3 (PMID: 19828133). The Taipale lab has an unpublished HT-SELEX model; both it and the inferred B1H motif seem very weak, supporting the idea that the homodimer does not bind DNA well. |
| SIM1 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
Similar to SIM2, which is a likely obligate heteromer. |
| SIM2 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
Likely obligate hetereomer (PMID: 7592839) |
| SOHLH1 |
bHLH |
Yes |
Likely to be sequence specific TF |
2 Obligate heteromer |
No motif |
|
Forms SOHLH1-SOHLH2 heterodimers (PMID: 22056784). |
| SOHLH2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SREBF1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SREBF2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TAL1 |
bHLH |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
No motif yielded from PBMs or HT-SELEX. Binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA). |
| TAL2 |
bHLH |
Yes |
Inferred motif |
2 Obligate heteromer |
In vivo/Misc source |
|
No motif yielded from PBMs or HT-SELEX. Similar to TAL1, which binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA). |
| TCF12 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TCF15 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TCF21 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TCF23 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Basic region is very similar to TCF21, which binds DNA as a homodimer in HT-SELEX. |
| TCF24 |
bHLH |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TCF3 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TCF4 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TCFL5 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TFAP4 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Also can form heterodimers (PMID: 26550823). |
| TFE3 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TFEB |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TFEC |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TWIST1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Can form both homodimers and heterodimers with TCF3 (PMID: 16502419). |
| TWIST2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| USF1 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| USF2 |
bHLH |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
Has a putative AT-hook |
|
| USF3 |
bHLH |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| POGK |
Brinker |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| AC023509.3 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
Identical bZIP DBD to ATF7. Some isoforms also contain a single C2H2 ZF. This is known to facilitate protein interactions in ATF7 (see ATF7 Uniprot page), so AC023509.3 is only classified here as a bZIP protein |
| APC2 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding |
| ATF1 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| ATF2 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ATF3 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ATF4 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ATF5 |
bZIP |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Transfac motifs dont correspond to canonical bZIP binding sites. Annotated as obligate heteromer based on peptide array studies (PMID:12805554). |
| ATF6 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ATF6B |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ATF7 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Some isoforms also contain a single C2H2 ZF. This is known to facilitate protein interactions (see Uniprot page), so ATF7 is only classified here as a bZIP protein |
| BACH1 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| BACH2 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Based on Newman et al 2003 (PMID: 12805554), the protein has strong preference for forming heterodimers with MAFG and MAFK over homo-dimerisation. The Homer ChIP-seq motif appears to be a MAF-BACH2 heterodimer. |
| BATF |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Prefers to heterodimerize, but it has an HT-SELEX (homodimer) motif. Its homodimerization Kd is 184nM and its best heterodimer is with CEBPG (<1nM) (PMID: 23661758). |
| BATF2 |
bZIP |
Yes |
Likely to be sequence specific TF |
2 Obligate heteromer |
No motif |
|
Part of AP-1 complex - there is no evidence it can bind on its own as a homodimer. |
| BATF3 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Transfac motif is dubious. |
| BEND4 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Lacks the basic region of the bZIP domain. |
| CCDC3 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
bZIP domain is truncated and lacks the DNA-contacting residues. |
| CCDC83 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
bZIP domains are truncated, such that they are likely just coiled-coiled regions with no DNA-binding ability. |
| CEBPA |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| CEBPB |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CEBPD |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
CEBPD binds as both a homodimer and as a heterdimer with other C/EBP TFs (PMID: 1884998; PMID: 12805554). |
| CEBPE |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Also forms heterodimers. |
| CEBPG |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CREB1 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CREB3 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CREB3L1 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CREB3L2 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| CREB3L3 |
bZIP |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Gel-shift and reporter experiments demonstrate that CREB3L3 is a TF (PMID: 11353085). |
| CREB3L4 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CREB5 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CREBL2 |
bZIP |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CREBRF |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Tested on HT-SELEX and did not yield a motif. Binds to CREB3 and represses the unfolded protein response (PMID: 18391022). |
| CREBZF |
bZIP |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| CREM |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| DBP |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| DDIT3 |
bZIP |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Has strong preference for forming heterodimers with BATF; DBP; HLF; CEBP[ABCD] over homodimerization (PMID: 12805554). |
| FOS |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| FOSB |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| FOSL1 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| FOSL2 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Also forms heterodimers. |
| GULP1 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding |
| HLF |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HOOK2 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding |
| IQGAP1 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
bZIP domain in the protein is just a fragment. |
| JDP2 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| JUN |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| JUNB |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Prefers forming heterodimers with FOS; FOSB; FOSL1 and FOSL2 over homodimers (PMID:12805554); but, clearly can bind DNA specifically in vitro. |
| JUND |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KIF15 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Has a bZIP like fragment that lacks the basic region required for DNA binding and a STE-domain that is classified as a potential DBD in CIS-BP. It is a kinesin operating in the microtubule system (PMID: 24419385) |
| KRT13 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding |
| MAF |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MAFA |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MAFB |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
PDB:2WTY is a homodimer crystallised with TAATTGCTGACTCAGCAAAT sequence |
| MAFF |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MAFG |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MAFK |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MORC3 |
bZIP |
No |
ssDNA/RNA binding |
4 Not a DNA binding protein |
No motif |
|
Lacks a canonical bZIP DBD but: regulates TP53 activity (PMID: 17332504]), binds RNA in vitro (PMID: 11927593), and may be required for influenza A transcription during viral infection (PMID: 26202233). |
| NDC80 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding |
| NFE2 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NFE2L1 |
bZIP |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Tested on HT-SELEX and PBM. Neither yielded a motif. Likely an obligate heteromer (PMID: 23661758). |
| NFE2L2 |
bZIP |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Has been tested by both PBM and HT-SELEX. Neither yielded a motif. Likely obligate heteromer. |
| NFE2L3 |
bZIP |
Yes |
Known motif |
2 Obligate heteromer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Tested on HT-SELEX and PBM. Neither yielded a motif. Likely an obligate heteromer (PMID: 23661758). Strong preference for forming heterodimers with MAFG and MAFK over homodimers (PMID: 12805554). |
| NFIL3 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| NRBF2 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding |
| NRL |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| PPP1R21 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Protein lacks the basic region these proteins use to contact the DNA |
| RAB11FIP4 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Likely false-positive - appears to function primarily in the cytoplasm (PMID: 12470645). |
| RNF219 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Not a proper bZIP; contains only a small leucine zipper region but lacks the DNA-interfacing basic part. |
| SCOC |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Not a proper bZIP; contains only a small leucine zipper region but lacks the DNA-interfacing basic part. |
| TEF |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TRAK2 |
bZIP |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
The bZIP domain is only a partial 40AA sequence that will not bind DNA. |
| XBP1 |
bZIP |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| AC008770.3 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| AC092835.1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
KRAB C2H2 Protein |
| AC138696.1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| AEBP2 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| AKAP8 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
(PMID: 26683827) uses SELEX to show binding to G/C rich DNA, and confirms association with rDNA promoters. Also claims it has a C2H2 domain. Interpro says it has a C2H2 AKAP95-type 1 and a C2H2 AKAP95-type 2 domain. SMART does identify a single C2H2 domain. |
| AKAP8L |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
This is homologous to the AKAP8/AKAP95 protein. which has been shown by SELEX to bind GC rich sequences (PMID: 26683827). |
| ANKZF1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
|
| ATMIN |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| BCL11A |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| BCL11B |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| BCL6 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| BCL6B |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| BNC1 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| BNC2 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Has a putative AT-hook |
|
| CASZ1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| CCDC17 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
|
| CHAMP1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
|
| CPXCR1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
|
| CTCF |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
Has a putative AT-hook |
|
| CTCFL |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| DPF1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
This protein contains C2H2 ZFs missed by Pfam scanning. |
| DPF3 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
Single C2H2 domain |
Single C2H2 ZF. PHD domains mediate recognition of acetylated histones (PMID: 20613843); unclear if the ZF contributes DNA-binding specificity to the interaction. |
| DZIP1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain; Has a putative AT-hook |
|
| E4F1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| EEA1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Based on (PMID: 20534488), the protein has a C2H2 ZF domain; but it uses the domain for contacting RAB5A rather than for binding DNA. |
| EGR1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| EGR2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Binds HOX4A promoter (PMID:21836637) |
| EGR3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| EGR4 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| FAM170A |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Degenerate C2H2-ZFP. Localizes to the nucleus and overexpression upregulates other genes (PMID: 20162441). |
| FEZF1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| FEZF2 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| FIZ1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Protein has a decent cassette of C2H2 ZF domains (not all are detected by Pfam). It has been also shown to interact with homeodomain protein CRX (PMID: 18854042) and MAF-subtype bZIP protein NRL (PMID: 12566383). |
| GFI1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| GFI1B |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| GLI1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| GLI2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| GLI3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| GLI4 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
Protein is not closely homologous to GLI1-3 proteins. |
| GLIS1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| GLIS2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| GLIS3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| GTF3A |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| GZF1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| HIC1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HIC2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HINFP |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| HIVEP1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| HIVEP2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| HIVEP3 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Has a putative AT-hook |
Binds to NFKB-like consensus sequence to repress transcription (PMID: 21189157). PWMs for HIVEP1 and 2 in Transfac and Hocomoco are also NFKB-like. |
| HKR1 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| IKZF1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| IKZF2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| IKZF3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| IKZF4 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| IKZF5 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| INSM1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| INSM2 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| JAZF1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| KAT7 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| KCMF1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
No evidence of DNA-binding in the literature; and has evidence of E3 ligase activity (PMID:15581609). |
| KIN |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Binds curved DNA (PMID: 8078469). |
| KLF1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF10 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF11 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF12 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF13 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF14 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF15 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF16 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF17 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF4 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF5 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Binds as a monomer and as a dimer (PMID: 25575120). |
| KLF6 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| KLF7 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| KLF8 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| KLF9 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| L3MBTL1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Histone modifier; polycomb protein. |
| L3MBTL3 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Histone modifier; polycomb protein. |
| L3MBTL4 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Histone modifier; polycomb protein. |
| MAZ |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| MECOM |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| MTF1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MYNN |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| MYT1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Crystal structure (PDB:2JX1) has GTGAACTTTCGGT DNA; similar to MYT1L SELEX and PBM sites. |
| MYT1L |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| MZF1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| NUFIP1 |
C2H2 ZF |
No |
ssDNA/RNA binding |
4 Not a DNA binding protein |
No motif |
Single C2H2 domain |
This is a known RNA-binding protein with a single C2H2 domain. TF-CAT considered it a candidate TF; but in the ten years since; no such evidence has emerged. |
| OSR1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| OSR2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| OVOL1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| OVOL2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| OVOL3 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| PEG3 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
SCAN C2H2 ZF Protein. |
| PLAG1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| PLAGL1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| PLAGL2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| PRDM1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| PRDM10 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Has a putative AT-hook |
|
| PRDM12 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| PRDM13 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| PRDM14 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| PRDM15 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| PRDM16 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| PRDM2 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Has been suggested to function as a histone methyltransferase (PMID: 15282304), but it has a decent set of C2H2 ZF domains and could thus bind DNA independently. |
| PRDM4 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| PRDM5 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Has a nice cassette of C2H2 ZF domains. Moreover, (PMID: 17636019) has performed SELEX for it and validated the result. |
| PRDM6 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| PRDM8 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| PRDM9 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| PRMT3 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Has a single C2H2 ZF (PMID: 10931850). |
| RBAK |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| RBSN |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Potential false positive - protein functions in membrane trafficking. |
| REPIN1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Binds DNA specifically based on EMSA and nuclease footprinting (PMID: 10606657). |
| REST |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| RLF |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| RREB1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| SALL1 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| SALL2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| SALL3 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| SALL4 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| SCRT1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SCRT2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SLC2A4RG |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Two papers demonstrate a bit of evidence for DNA binding (PMID:10825161 and PMID: 14625278 ). |
| SNAI1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SNAI2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SNAI3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SP1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SP2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SP3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SP4 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SP5 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Transfac motif has some similarity to known Sp1 TF motifs from multiple species and sources |
| SP6 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SP7 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| SP8 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| SP9 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ST18 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| TRAFD1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Possible false positive: the protein negatively regulates IRF3 and NFKB but there is no evidence for DNA-binding and it is likely to operate upstream on the signalling cascade (PMID:18849341). |
| TSHZ1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| TSHZ2 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Also contains an atypical homodomain (Uniprot) not identified by Pfam. |
| TSHZ3 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
The C2H2 domains are too spread out to be credible; but there is also a homodomain. Seems more likely than not that it binds DNA. |
| VEZF1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| WIZ |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Has a putative AT-hook |
Regulates the G9aGLP complex for gene repression; has a ChIP-seq derived DNA-binding motif (PMID:25789554). |
| WT1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
Crystal structure (PDB:2JP9) is with dsDNA GCGCAGACGCCCCCGCG, which is consistent with the PWMs |
| YY1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| YY2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| ZBTB10 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain |
| ZBTB11 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| ZBTB12 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB14 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB16 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| ZBTB17 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBTB18 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB20 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB21 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain |
| ZBTB22 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB25 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBTB26 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| ZBTB32 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB33 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| ZBTB34 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB37 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB38 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
It has a decent cassette of znfC2H2 domains and a BTB homodimerization domain. Requires CpG methylation for binding into a site in MYOG-promoter (PMID: 21625269). |
| ZBTB39 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBTB4 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| ZBTB40 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain |
| ZBTB41 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBTB42 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZBTB43 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB44 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB45 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB46 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Specificity is unknown; functions in dendritic cells (PMID: 22615130). |
| ZBTB47 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZBTB48 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZBTB49 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB5 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Binds to GATCGGGCGGGGCGGTTGTATATCA; GATCCGTTAGAGGAAGAAGACTGGGCATGTCTG and GATCCATCAGGAACATGTCCCAACATGTTGAGCTC based on EMSA using recombinant protein (PMID: 19491398). |
| ZBTB6 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZBTB7A |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB7B |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB7C |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZBTB8A |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a two znfC2H2 domains and a BTB-domain |
| ZBTB8B |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain |
| ZBTB9 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has two znfC2H2 domains and a BTB-domain that typically mediates homotypic dimerization |
| ZFAT |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Has a putative AT-hook |
|
| ZFP1 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZFP14 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZFP2 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| ZFP28 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE); Has a putative AT-hook |
|
| ZFP3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZFP30 |
C2H2 ZF(KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZFP37 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZFP41 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZFP42 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZFP57 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
Recognizes CpG methylated ACTGCGGCAAT site based on structure 4GZN |
| ZFP62 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains |
| ZFP64 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZFP69 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZFP69B |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZFP82 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZFP90 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZFP91 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Possible false positive. An Atypical E3 ubiquitin-protein ligase that mediates Lys-63-linked ubiquitination of MAP3K14/NIK; leading to stabilization and activation of MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway (PMID: 20682767). |
| ZFP92 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZFPL1 |
C2H2 ZF |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
Protein is a Golgi apparatus integral membrane protein with RING-type zinc fingers (PMID:18323775 ). |
| ZFPM1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZFPM2 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
FOG-proteins use some of their zinc-fingers to interact with the GATA proteins. Other C2H2 ZFs are probably also capable of binding DNA (PMID: 10329627). |
| ZFR |
C2H2 ZF |
No |
ssDNA/RNA binding |
4 Not a DNA binding protein |
No motif |
|
|
| ZFR2 |
C2H2 ZF |
No |
ssDNA/RNA binding |
4 Not a DNA binding protein |
No motif |
|
ZFR2 contains only RNA-binding zinc fingers |
| ZFX |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| ZFY |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| ZIC1 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZIC2 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
100 perc ID - in vitro |
|
|
| ZIC3 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZIC4 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZIC5 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZIK1 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZIM2 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
Binds GKGGSWST consensus with GTGGCAGT as the optimal site based on competition EMSA (PMID: 26692216). |
| ZIM3 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZKSCAN1 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZKSCAN2 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZKSCAN3 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZKSCAN4 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZKSCAN5 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZKSCAN7 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZKSCAN8 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZMAT1 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
Single C2H2 domain |
Possible RBP. |
| ZMAT3 |
C2H2 ZF |
No |
ssDNA/RNA binding |
4 Not a DNA binding protein |
No motif |
|
Protein binds RNA (PMID: 19805223 and PMID: 16844115). |
| ZMAT4 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Possible RBP. |
| ZNF10 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF100 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF101 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF106 |
C2H2 ZF |
No |
Unlikely to be sequence specific TF |
4 Not a DNA binding protein |
No motif |
|
C2H2 ZFs are not present in most isoforms; of which most contain WD40 repeats. Previous annotations (TFCat) suggest role as a cofactor (PMID: 15833274). |
| ZNF107 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZNF112 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Has a nice cassette of znfC2H2 domains and a KRAB-domain; virtually nothing is known about it. |
| ZNF114 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF117 |
C2H2 ZF(non-KRAB) |
Yes |
Inferred motif |
1 Monomer or homomultimer |
In vivo/Misc source |
|
|
| ZNF12 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF121 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF124 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF131 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Evidence for DNA binding (PMID: 20303951 ). |
| ZNF132 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF133 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF134 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF135 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF136 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF138 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF14 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains |
| ZNF140 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF141 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF142 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF143 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF146 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF148 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| ZNF154 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF155 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF157 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF16 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF160 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZNF165 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain and that it appears to be expressed commonly in urinary bladder cancers PMID: 25214475 |
| ZNF169 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF17 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF174 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF175 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF177 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF18 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF180 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF181 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF182 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF184 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF189 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF19 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF195 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Kruppel family C2H2 ZF. |
| ZNF197 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF2 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF20 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF200 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF202 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF205 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF207 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF208 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF211 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF212 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF213 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE); Has a putative AT-hook |
|
| ZNF214 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF215 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF217 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Based on (PDB: 3UK3) this protein has at least two DNA binding znf domains. In vitro evidence for DNA binding (PMID:17130829). |
| ZNF219 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Binds CCCCCA based on SELEX (PMID: 14621294). |
| ZNF22 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF221 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF222 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF223 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF224 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF225 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF226 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF227 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF229 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZNF23 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF230 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Has nice array of znf domains and a KRAB domain |
| ZNF232 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF233 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF234 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF235 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF236 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| ZNF239 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Binds TAAAGGCT based on EMSA (PMID: 11278819). |
| ZNF24 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF248 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF25 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF250 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF251 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZNF253 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZNF254 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF256 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZNF257 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF26 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF260 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF263 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF264 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF266 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF267 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF268 |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Contains znfC2H2 domains and a KRAB-domain; linked to cervical cancer through effects on NFKB-signaling (PMID: 23091055). |
| ZNF273 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF274 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF275 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF276 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF28 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF280A |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF280B |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF280C |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF280D |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF281 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF282 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF283 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF284 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF285 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF286A |
C2H2 ZF(KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain |
| ZNF286B |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains |
| ZNF287 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF292 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
|
| ZNF296 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF3 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF30 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF300 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF302 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF304 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF311 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect |
|
| ZNF316 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
In vivo/Misc source |
Only known motifs are from Transfac or HocoMoco - origin is uncertain |
|
| ZNF317 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF318 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Possible RNA-binding protein; it has two u1 type ZNF domains (PMID: 25057009). |
| ZNF319 |
C2H2 ZF(non-KRAB) |
Yes |
Likely to be sequence specific TF |
1 Monomer or homomultimer |
No motif |
|
Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains |
| ZNF32 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
|
|
| ZNF320 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF322 |
C2H2 ZF(non-KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF324 |
C2H2 ZF(KRAB) |
Yes |
Known motif |
1 Monomer or homomultimer |
High-throughput in vitro |
ChIP-seq motif is consistent with recognition code (RCADE) |
|
| ZNF324B |
C2H2 ZF(KRAB) |
Yes |