Collection of 17 putative T-box human TFs out of 17 considered proteins

DBD Alignment (Click to open/enlarge)


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Description
The T-box family of TFs has 17 members in human, many of which have been shown to function in extra-embryonic tissues such as placenta, in early development during mesoderm formation and also in later developmental contexts such as tissue morphogenesis. The developmental roles of T-box TFs are highlighted by the fact that at least ten of the T-box TFs cause embryonic or neonatal death in knockout mice, and many of them are connected to different developmental disorders. The DBD of T-box factors is large and bulky, offering broad surfaces for protein-protein interaction, and it contacts both major- and minor grooves of the DNA. The recognition mechanism is however mostly indirect, as the DBD contacts the bases on the major groove with only a single hydrogen bond and from the minor groove side by phenylalanines that insert to minor groove of the DNA, while the rest of the contacts target the backbone positions of the DNA 		Structure
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
EOMES T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
MGA T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Has a putative AT-hook Some isoforms also contain a predicted bHLH domain, but it is unlike any other known bHLH domain and the MGA motif looks like a standard T-box motif, so the bHLH domain is likely a false positive
T T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBR1 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX1 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX10 T-box Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro
TBX15 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX18 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX19 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX2 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX20 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX21 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX22 T-box Yes Known motif 1 Monomer or homomultimer In vivo/Misc source
TBX3 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX4 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Available motifs suggest facultative homodimeric binding
TBX5 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TBX6 T-box Yes Known motif 1 Monomer or homomultimer High-throughput in vitro