Collection of 7 putative STAT human TFs out of 7 considered proteins
DBD Alignment (Click to open/enlarge)
| Description The STAT family has 7 members. All STAT-TFs need to be activated by phosphorylation of certain tyrosine residues in order to be transported into the nucleus from their general cytoplasmic locations and to bind to DNA. STAT-TFs are used by cells in interferon signaling. All STAT TFs recognize very similar individual target sites where TTC[2-4N]GAA consensus is bound by homodimeric configurations of the TFs. Most of the family members prefer either 3N (at least STAT[1,2A,2B]) or 4N (STAT6). Based on the crystal structure of STAT1, the STATs are also capable of binding DNA as monomers. The STAT domain is massive when compared to most other DBDs |
Structure |
| Ensembl ID | HGNC symbol | DBD Family | Is TF? | TF Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|---|---|---|---|
| STAT1 | STAT | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | |||
| STAT2 | STAT | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | |||
| STAT3 | STAT | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | |||
| STAT4 | STAT | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | ||
| STAT5A | STAT | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | ||
| STAT5B | STAT | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | Can form both homodimers and heterodimers with STAT5A (PMID: 9528750) | |
| STAT6 | STAT | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain |