Collection of 9 putative SAND human TFs out of 10 considered proteins

DBD Alignment (Click to open/enlarge)


Click to download Alignment and Tree
No Structure and Description available
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
AIRE SAND Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds to TTATTA and tandem repeats of ATTGGTTA (PMID: 11533054)
DEAF1 SAND Yes Inferred motif 1 Monomer or homomultimer In vivo/Misc source
GLA SAND No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif GLA appears to lack a functional SAND domain. It encodes a well-characterized enzyme, Galactosidase Alpha. Most of the polypeptide encodes a glycoside hydrolase domain and most of the rest encodes another pfam domain called Glycoside hydrolase family 27. It has a low-scoring SAND domain match that almost certainly overlaps with a known domain related to its function as an enzyme.
GMEB1 SAND Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
GMEB2 SAND Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
SKOR2 SAND Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
SP100 SAND Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Gel-shift experiments using human SP100 have shown binding to specific TTCG half sites (PMID: 11427895).
SP110 SAND Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif
SP140 SAND Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif
SP140L SAND Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif