Collection of 4 putative Paired box human TFs out of 4 considered proteins
DBD Alignment (Click to open/enlarge)
| Description There are 9 TFs with a PAX domain, four of which, PAX[3,4,6,7], contain also a functional homeodomain (IPR001356). The PAX domain is composed of two folded domains that are connected by a tethering region, but unlike in many other TFs with this type of layout the tethering region is an active participant in the DNA-binding which inserts fully into the minor groove of DNA. |
Structure |
| Ensembl ID | HGNC symbol | DBD Family | Is TF? | TF Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|---|---|---|---|
| PAX1 | Paired box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| PAX5 | Paired box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| PAX8 | Paired box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| PAX9 | Paired box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro |