Collection of 46 putative Nuclear receptor human TFs out of 46 considered proteins
DBD Alignment (Click to open/enlarge)
No Structure and Description available
| Ensembl ID | HGNC symbol | DBD Family | Is TF? | TF Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|---|---|---|---|
| AR | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| ESR1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| ESR2 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro | |||
| ESRRA | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| ESRRB | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| ESRRG | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| HNF4A | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| HNF4G | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | |||
| NR1D1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR1D2 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR1H2 | Nuclear receptor | Yes | Known motif | 2 Obligate heteromer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | Likely an obligate heteromer (PMID: 7935418; PMID: 7892230; PMID: 7744246) | |
| NR1H3 | Nuclear receptor | Yes | Inferred motif | 2 Obligate heteromer | In vivo/Misc source | Binds as an obligate heterodimer with RXR-proteins. (PDB: 2ACL) is a crystal structure of the two proteins without DNA | ||
| NR1H4 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | Also binds DNA as heterodimer with RXRA (PMID: 11870371) | ||
| NR1I2 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR1I3 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR2C1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR2C2 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR2E1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR2E3 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR2F1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR2F2 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro | |||
| NR2F6 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR3C1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR3C2 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR4A1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR4A2 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR4A3 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | ||
| NR5A1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR5A2 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| NR6A1 | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| PGR | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| PPARA | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | ||
| PPARD | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| PPARG | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro | Also heterodimerizes. | ||
| RARA | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| RARB | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| RARG | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| RORA | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| RORB | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| RORC | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| RXRA | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| RXRB | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | Has been shown to bind both as a homodimer and with several nuclear receptor homodimerization partners | ||
| RXRG | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | Usually binds in vivo as a heterodimer, but can bind as a homodimer in vitro | ||
| THRA | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | Likely binds as a heterodimer too | ||
| THRB | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| VDR | Nuclear receptor | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro |