Collection of 14 putative Myb/SANT human TFs out of 38 considered proteins

DBD Alignment (Click to open/enlarge)


Click to download Alignment and Tree
No Structure and Description available
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
C17orf49 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 1 SANT domain, suggesting it cannot bind DNA specifically
CDC5L Myb/SANT Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Compelling evidence for DNA binding (PMID: 11082045).
CHD2 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook Although CHD2 has weak similarity to a Myb domain (PMID: 9326634), its more closely related to the non-DNA-binding SANT domain based on the alignment analysis. The data showing that show that CHD2 binding histone H3.3 (PMID:22569126) further support the conclusion that the Myb domain is probably a SANT domain facilitating the histone interaction
CRAMP1 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains a single SANT domain, no evidence for sequence-specific DNA binding
DMTF1 Myb/SANT Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Contains 2 Myb DBDs. Binds to CCCG(G/T)ATGT (PMID: 8887674)
DNAJC1 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 2 SANT domains, and no other putative DNA-binding domains
DNAJC2 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 2 SANT domains, and no other putative DNA-binding domains
ELMSAN1 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains a single SANT domain, no evidence for sequence-specific DNA binding
KIAA1841 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Domain is truncated, and there is nothing known about this gene
MIER1 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains a single SANT domain, no evidence for sequence-specific DNA binding
MIER2 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Has a putative AT-hook MIER2s Myb domain is more similar to the non-DNA-binding SANT domain
MIER3 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif MIER3s Myb domain is more similar to the non-DNA-binding SANT domain. Tested on both PBM and HT-SELEX, with no motif.
MIS18BP1 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 1 SANT domain, and a SANTA domain
MSANTD4 Myb/SANT Yes Likely to be sequence specific TF 3 Low specificity DNA-binding protein No motif Contains a single Myb-like domain with an insertion in the middle. It is ambiguous whether Myb-like domains are DNA or protein binding. Since it has a single domain its likely non-specific.
MYB Myb/SANT Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Contains 3 Myb DBDs
MYBL1 Myb/SANT Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Contains 3 Myb DBDs
MYBL2 Myb/SANT Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Contains 3 Myb DBDs
MYPOP Myb/SANT Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Contains a single Myb-like domain. Mouse ortholog has motif
MYSM1 Myb/SANT Yes Likely to be sequence specific TF 3 Low specificity DNA-binding protein No motif MYSM1 has been shown to bind DNA. This interaction requires the MYSM1 Myb but not the SWIRM domain (PMID: 17428495). Domain sequence alignment places it near DNA-binding Myb domains but scores slightly higher as a SANT rather than Myb domain based on Prosite patterns. Given that most Myb proteins that bind DNA sequence specifically have multiple Myb domains in an array, this protein could bind DNA sequence non-specifically with its single Myb domain.
NCOR1 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 2 SANT domains, and no other putative DNA-binding domains. Member of N-CoR deacetylase complex (PMID: 14527417).
NCOR2 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 2 SANT domains, and no other putative DNA-binding domains
PRDM11 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif SANT domain containing protein. Mouse Prdm11 contains Myb-like domain and binds DNA in PBM experiments but has low sequence identity (21%)
RCOR1 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 2 SANT domains, and no other putative DNA-binding domains. Plays a well-established co-repressor role in the histone LSD1/RCOR1 de-methylase complex. There is some evidence that the protein contacts extranucleosomal DNA (PMID: 25916846).
RCOR2 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 2 SANT domains, and no other putative DNA-binding domains
RCOR3 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 2 SANT domains, and no other putative DNA-binding domains. RCOR3 SANT domains are known to facilitate PPIs. Known co-repressor - likely recruited by multiple TFs, as reviewed in (PMID: 24820421).
SMARCA1 Myb/SANT No Unlikely to be sequence specific TF 3 Low specificity DNA-binding protein No motif SMARCA1 contains a truncated Myb-like and SANT domain. Given the presence of the Myb-like domain, and other domains known to associated with DNA (DEAD box helicase) it likely associates with DNA non-sequence-specifically
SMARCA5 Myb/SANT No Unlikely to be sequence specific TF 3 Low specificity DNA-binding protein No motif Has a putative AT-hook Contains a SANT, and Myb-like domain. Chromatin remodeling complex component that operates in DNA repair (PMID: 24990377); interacts with DNA, but presumably in non-sequence specific manner.
SMARCC1 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 1 SANT domain, and no other putative DNA-binding domains. Given that SMARCC1 is part of the Swi/Snf chromatin remodelling complex, its Myb/Sant domain is likely involved in binding histone tails. Available motif logos ares likely specificifities of SMARCC1 interactors.
SMARCC2 Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains 1 SANT domain, and no other putative DNA-binding domains. Available motif logos ares likely specificifities of SMARCC2 interactors.
SNAPC4 Myb/SANT Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif EMSA data available showing it can specifically bind DNA (PMID: 9418884)
TADA2A Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif TADA2A contains a single SANT domain and is thus unlikely to bind DNA
TADA2B Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif TADA2B contains a single SANT domain and is thus unlikely to bind DNA
TERB1 Myb/SANT Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Contains a single Myb domain (with slightly less similarity to a SANT domain). This domain has been shown to be involved in PPIs (PMID: 24413433), but this may not be mutually exclusive with DNA-binding.
TERF1 Myb/SANT Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Contains 1 Myb domain, and has structural evidence of DNA-binding (PDB: 1IV6). Subunit of Shelterin, a complex that specifically binds telomeres (PMID: 16166375).
TERF2 Myb/SANT Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro The sequence in the crystal structure (PDB:1VFC), GTTAGGGTTAGGG, matches the inferred mouse motif.
TERF2IP Myb/SANT No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Contains a single Myb-like domain. Forms a complex with TERF2, where it modulates the binding of TERF2 to telomeres (PMID: 25675958). Unclear if TERF2IP contacts DNA directly.
TTF1 Myb/SANT Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Contains Myb and Myb-like domains, and is annotated as a Pol1 terminator. DNA-binding has been demonstrated in vitro via EMSA (PMID: 7597036).
ZZZ3 Myb/SANT Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Contains 1 Myb DBD