Collection of 6 putative MADS box human TFs out of 6 considered proteins
DBD Alignment (Click to open/enlarge)
| Description MADS is an ancient TF-family with members occurring in species from all three kingdoms of life. It is a very prominent family in plants but relatively small in vertebrates with just five TFs in human. Besides the HMG TFs, this is the second class of TFs that contacts mostly the minor groove of the DNA instead of the major groove, and similarly to HMG-TFs this is also accompanied by a large shift in the shape of the DNA. |
Structure |
| Ensembl ID | HGNC symbol | DBD Family | Is TF? | TF Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|---|---|---|---|
| BORCS8-MEF2B | MADS box | Yes | Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro | |||
| MEF2A | MADS box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| MEF2B | MADS box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| MEF2C | MADS box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| MEF2D | MADS box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro | |||
| SRF | MADS box | Yes | Known motif | 1 Monomer or homomultimer | High-throughput in vitro |