Description
There are two GCM TFs in human. Both are connected to neural function, and the name of the class “Glial cells missing” is derived from this. Similar to C2H2 zinc fingers and nuclear receptors, this TF is also folded around coordinated zinc ions, but this is likely to be a consequence of convergent evolution, as the fold is very different from that of the zinc finger domain TFs. GCM proteins are conserved broadly in metazoans, existing both in Drosophila and mammals. GCM factors recognize a distinct NATGCGGGTAC consensus with a long interface to the major groove of the DNA but with no contacts to the minor groove positions or the backbone.
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Structure
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