Collection of 10 putative GATA human TFs out of 11 considered proteins

DBD Alignment (Click to open/enlarge)


Click to download Alignment and Tree
Description
A GATA domain is found in approximately 10 proteins, and at least six of them GATA 1 to 6 are proven sequence specific TFs. Similarly to FOX TFs, the GATA-family members can function as pioneer factors that can bind to their target sites even when the sequences that contain the sites are loaded with nucleosomes. GATA 1 to 6 TFs have two zinc coordinated DBDs that are connected to each other by a flexible linker sequence, the C-terminal of which binds to the canonical GATAA-target site in DNA, whereas the N-terminal domain binds to GATC-sequences if present in composite sites. Alternatively, the N-terminal DBD can serve as a protein-protein interaction interface with its binding partner ZFPM1 that is also known as “Friend of Gata”FOG1 		Structure
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
GATA1 GATA Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
GATA2 GATA Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
GATA3 GATA Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
GATA4 GATA Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
GATA5 GATA Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
GATA6 GATA Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
GATAD1 GATA No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif The GATA domain is truncated (see alignment)
GATAD2A GATA Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Has the full GATA domain, and JPRED4 thinks the secondary structure is preserved. The GATA domain is not sufficiently well studied to declare that specific amino acids are absolutely required in order to bind DNA. Many unusual GATA domain proteins across eukaryotes bind DNA, making it reasonable to project that this one does, too.
GATAD2B GATA Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Has the full GATA domain, and JPRED4 thinks the secondary structure is preserved. The GATA domain is not sufficiently well studied to declare that specific amino acids are absolutely required in order to bind DNA. Many unusual GATA domain proteins across eukaryotes bind DNA, making it reasonable to project that this one does, too.
TRPS1 GATA Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain
ZGLP1 GATA Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif