Collection of 27 putative Ets human TFs out of 27 considered proteins

DBD Alignment (Click to open/enlarge)


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Description
There are 27 ETS TFs in human, and the family is structurally related to FOXes as they also recognize the DNA with a winged helix-turn-helix type of domain. Many of the ETS TFs have prominent roles in basal cellular functions, their target sites occur commonly on promoter regions near the TSS, and many of them are connected to particular forms of cancers 		Structure
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
EHF Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ELF1 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ELF2 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ELF4 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ELF5 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ELK1 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ELK3 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ELK4 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ERF Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ERG Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETS1 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETS2 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETV1 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETV2 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETV3 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETV3L Ets Yes Known motif 1 Monomer or homomultimer 100 perc ID - in vitro
ETV4 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETV5 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETV6 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
ETV7 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Experimental low-throughput evidence of DNA-binding and changes in reporter expression (PMID: 11108721)
FEV Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FLI1 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
GABPA Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
SPDEF Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
SPI1 Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
SPIB Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
SPIC Ets Yes Known motif 1 Monomer or homomultimer High-throughput in vitro