Collection of 9 putative CxxC human TFs out of 9 considered proteins

DBD Alignment (Click to open/enlarge)


Click to download Alignment and Tree
Description
 Structure
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
CXXC1 CxxC Yes Known motif 1 Monomer or homomultimer High-throughput in vitro X-ray structure (PDB:3QMI) indicates sequence specific binding through base contacts (PMID: 21407193).
CXXC4 CxxC Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Binds unmethylated CpG-rich sequences: (PMID: 23563267).
CXXC5 CxxC Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
DNMT1 CxxC Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FBXL19 CxxC Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif
KDM2A CxxC Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Has a CXXC zinc finger that recognizes CGs (PMID: 22083960)
KDM2B CxxC Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TET1 CxxC Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TET3 CxxC Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif