Binds with consensus AAWANAAAWAAWT and AATACAATTAAAT as strongest target sequences based on EMSA and SELEX (PMID: 20351289). Protein contains a winged helix structural domain (PMID: 12057194)
Description
Description:
Dachshund family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2663]
Entrez Summary
This gene encodes a chromatin-associated protein that associates
with other DNA-binding transcription factors to regulate gene expression and
cell fate determination during development. The protein contains a Ski domain
that is highly conserved from Drosophila to human. Expression of this gene is
lost in some forms of metastatic cancer, and is correlated with poor
prognosis. Multiple transcript variants encoding different isoforms have been
found for this gene. [provided by RefSeq, Sep 2009]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
No
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
GO:0001075 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved IBA - GO_REF:0000033 GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:20956529
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF