This gene encodes a protein which contains multiple domains
including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains,
and a SET (suppressor of variegation, enhancer of zeste, and trithorax)
domain. The SET domain is a conserved C-terminal domain that characterizes
proteins of the MLL (mixed-lineage leukemia) family. This gene is
ubiquitously expressed in adult tissues. It is also amplified in solid tumor
cell lines, and may be involved in human cancer. Two alternatively spliced
transcript variants encoding distinct isoforms have been reported for this
gene, however, the full length nature of the shorter transcript is not known.
[provided by RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:10409430
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF