| Source |
Annotation |
| TF-CAT classification |
No
PMIDS: |
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
|
b |
| CisBP considers it as a TF? |
Yes |
| TFclass considers it as a TF? |
Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" |
No |
| GO-Info |
GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
|
2a2, orthologous lower confidence evidence |
| TF has conditional DNA-binding requirements |
|