The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif		Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains

Description

Description:	zinc finger protein 286B [Source:HGNC Symbol;Acc:HGNC:33241]
Entrez Summary	TBA
Ensembl ID:	ENSG00000249459
External Link:
Interpro	IPR007087; IPR015880;
Protein Domain:
Protein: ENSP00000463300	DBD: C2H2 ZF Containing Proteins	Other:
Protein: ENSP00000460210	DBD: C2H2 ZF Containing Proteins	Other: RNA_pol_A_CTD
Protein: ENSP00000460736	DBD: C2H2 ZF Containing Proteins	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	No
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "jagged", "end": 51, "endStyle": "jagged", "aliStart": 24, "text": "RNA_pol_A_CTD", "colour": "#9999ff", "aliEnd": 45, "start": 17, "href": "http://pfam.xfam.org/family/PF03118.13", "type": "pfama", "display": "true", "metadata": {"end": 51, "description": "The alpha subunit of RNA polymerase consists of two independently folded domains, referred to as amino-terminal and carboxyl terminal domains.  The amino terminal domain is involved in the interaction with the other subunits of the RNA polymerase.  The carboxyl-terminal domain interacts with the DNA and activators.  The amino acid sequence of the alpha subunit is conserved in prokaryotic and chloroplast RNA  polymerases.  There are three regions of particularly strong  conservation, two in the amino-terminal and one in the carboxyl- terminal [2].", "database": "PfamA", "aliStart": 24, "scoreName": "E-value", "accession": "PF03118.13", "start": 17, "score": 0.0053, "identifier": "Bacterial RNA polymerase, alpha chain C terminal domain", "type": "DBD", "aliEnd": 45}}], "length": 66}

TF Info Page for ZNF286B (C2H2 ZF(non-KRAB))