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This gene encodes a transcription factor that belongs to NKX family
of homeodomain-containing proteins which are critical regulators of organ
development. In mice, the orthologous gene is expressed predominantly in the
brainstem, in the vicinity of serotonergic neurons, and is required for the
coordinated crosstalk of factors involved in the maintenance of energy
homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous
fat and intra-abdominal epididymal and mesenteric white adipose tissue two
weeks after birth, and die within three weeks after birth. [provided by
RefSeq, Jul 2017]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF