TF Info Page for YY2 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: YY2 transcription factor [Source:HGNC Symbol;Acc:HGNC:31684]
Entrez Summary The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]
Ensembl ID: ENSG00000230797
External Link: CisBP
Interpro IPR007087; IPR015880; IPR017114; ;
Protein Domain: ENSP00000389381
Domain:
Protein: ENSP00000389381DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
SMiLE-seqIsakova2017Inferred - YY1 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - YY1 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - YY1 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - YY1 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TYY2_RAT (81% AA Identity, Rattus norvegicus)
ChIP-seqENCODEInferred - YY1 (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - YY1 (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - YY1 (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - YY1 (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - YY1 (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - YY1 (81% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - YY1 (81% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - YY1 (81% AA Identity, Homo sapiens)
ChIP-seqNajafabadi2015Inferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - YY1 (81% AA Identity, Homo sapiens)
MiscHocoMocoInferred - YY1 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ZFP42 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ZFP42 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZFP42 (73% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution