TF Info Page for CPEB1 (Unknown)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro HT-SELEX motif could be an artefact of ssDNA binding activity, as CPEB1 is a well-characterized RNA-binding protein. Could not find evidence of CPEB1 DNA-binding activity in the literature

Description

Description: cytoplasmic polyadenylation element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:21744]
Entrez Summary This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Ensembl ID: ENSG00000214575
External Link: CisBP
Interpro IPR000504; ;
Protein Domain: ENSP00000477715
Protein Domain: ENSP00000477557
Protein Domain: ENSP00000478598
Protein Domain: ENSP00000483590
Protein Domain: ENSP00000483857
Protein Domain: ENSP00000479625
Protein Domain: ENSP00000484549
Protein Domain: ENSP00000455044
Domain:
Protein: ENSP00000477715DBD: OtherOther: CEBP1_N, CEBP_ZZ
Protein: ENSP00000477557DBD: OtherOther: CEBP1_N, CEBP_ZZ
Protein: ENSP00000478598DBD: OtherOther: CEBP1_N, CEBP_ZZ
Protein: ENSP00000483590DBD: OtherOther: CEBP1_N, CEBP_ZZ
Protein: ENSP00000483857DBD: OtherOther: CEBP1_N, CEBP_ZZ
Protein: ENSP00000479625DBD: OtherOther: CEBP1_N, CEBP_ZZ
Protein: ENSP00000484549DBD: OtherOther: CEBP1_N, CEBP_ZZ
Protein: ENSP00000455044DBD: OtherOther: CEBP1_N

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements RBP

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution