The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif		Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain

Description

Description:	zinc finger protein 726 [Source:HGNC Symbol;Acc:HGNC:32462]
Entrez Summary	TBA
Ensembl ID:	ENSG00000213967
External Link:
Interpro	IPR001909; IPR007087; IPR015880; ;
Protein Domain:
Protein: ENSP00000432583	DBD: C2H2 ZF Containing Proteins	Other: KRAB
Protein: ENSP00000461349	DBD: C2H2 ZF Containing Proteins	Other: KRAB
Protein: ENSP00000433319	DBD: C2H2 ZF Containing Proteins	Other: KRAB
Protein: ENSP00000334762	DBD: C2H2 ZF Containing Proteins	Other: KRAB

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	b
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "straight", "end": 44, "endStyle": "straight", "aliStart": 3, "text": "KRAB", "colour": "#9999ff", "aliEnd": 44, "start": 3, "href": "http://pfam.xfam.org/family/PF01352.25", "type": "pfama", "display": "true", "metadata": {"end": 44, "description": "The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].", "database": "PfamA", "aliStart": 3, "scoreName": "E-value", "accession": "PF01352.25", "start": 3, "score": 1.2e-25, "identifier": "KRAB box", "type": "DBD", "aliEnd": 44}}], "length": 78}

{"regions": [{"startStyle": "straight", "end": 44, "endStyle": "straight", "aliStart": 3, "text": "KRAB", "colour": "#9999ff", "aliEnd": 44, "start": 3, "href": "http://pfam.xfam.org/family/PF01352.25", "type": "pfama", "display": "true", "metadata": {"end": 44, "description": "The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].", "database": "PfamA", "aliStart": 3, "scoreName": "E-value", "accession": "PF01352.25", "start": 3, "score": 2.6e-25, "identifier": "KRAB box", "type": "DBD", "aliEnd": 44}}], "length": 110}

{"regions": [{"startStyle": "straight", "end": 44, "endStyle": "straight", "aliStart": 3, "text": "KRAB", "colour": "#9999ff", "aliEnd": 44, "start": 3, "href": "http://pfam.xfam.org/family/PF01352.25", "type": "pfama", "display": "true", "metadata": {"end": 44, "description": "The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].", "database": "PfamA", "aliStart": 3, "scoreName": "E-value", "accession": "PF01352.25", "start": 3, "score": 1.7000000000000002e-25, "identifier": "KRAB box", "type": "DBD", "aliEnd": 44}}], "length": 90}

{"regions": [{"startStyle": "straight", "end": 44, "endStyle": "straight", "aliStart": 3, "text": "KRAB", "colour": "#9999ff", "aliEnd": 44, "start": 3, "href": "http://pfam.xfam.org/family/PF01352.25", "type": "pfama", "display": "true", "metadata": {"end": 44, "description": "The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].", "database": "PfamA", "aliStart": 3, "scoreName": "E-value", "accession": "PF01352.25", "start": 3, "score": 2.5000000000000003e-25, "identifier": "KRAB box", "type": "DBD", "aliEnd": 44}}], "length": 109}

TF Info Page for ZNF726 (C2H2 ZF(KRAB))