TF Info Page for ATF6B (bZIP)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: activating transcription factor 6 beta [Source:HGNC Symbol;Acc:HGNC:2349]
Entrez Summary The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Ensembl ID: ENSG00000213676
External Link: CisBP
Interpro IPR004827; ;
Protein Domain: ENSP00000364347
Protein Domain: ENSP00000364349
Protein Domain: ENSP00000393419
Domain:
Protein: ENSP00000364347DBD: bZIPOther:
Protein: ENSP00000364349DBD: bZIPOther:
Protein: ENSP00000393419DBD: bZIPOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:11256944
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
3a, decent circumstantial evidence for its role as
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
HT-SELEXYin2017Inferred - ATF6B (100% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATF6B (100% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATF6B (100% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATF6B (100% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATF6B (100% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATF6 (59% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATF6 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATF6 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATF6 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ATF6 (59% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ATF6 (59% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution