POU class 5 homeobox 1B [Source:HGNC Symbol;Acc:HGNC:9223]
Entrez Summary
This intronless gene was thought to be a transcribed pseudogene of
POU class 5 homeobox 1, however, it has been reported that this gene can
encode a functional protein. The encoded protein is nearly the same length as
and highly similar to the POU class 5 homeobox 1 transcription factor, has
been shown to be a weak transcriptional activator and may play a role in
carcinogenesis and eye development. [provided by RefSeq, Apr 2009]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
c
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:1408763
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF