TF Info Page for DPF3 (C2H2 ZF)


Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro Single C2H2 domain Single C2H2 ZF. PHD domains mediate recognition of acetylated histones (PMID: 20613843); unclear if the ZF contributes DNA-binding specificity to the interaction.


Description: double PHD fingers 3 [Source:HGNC Symbol;Acc:HGNC:17427]
Entrez Summary This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Ensembl ID: ENSG00000205683
External Link: CisBP
Interpro IPR001965; IPR007087; IPR011011; IPR015880; IPR019787; IPR025750;
Protein Domain: ENSP00000441640
Protein Domain: ENSP00000450518
Protein Domain: ENSP00000444662
Protein Domain: ENSP00000479526
Protein: ENSP00000441640DBD: C2H2 ZF Containing ProteinsOther: Lar_restr_allev, PHD, Requiem_N
Protein: ENSP00000450518DBD: C2H2 ZF Containing ProteinsOther: PHD, PHD_4, Requiem_N
Protein: ENSP00000444662DBD: C2H2 ZF Containing ProteinsOther: Lar_restr_allev, PHD, Requiem_N
Protein: ENSP00000479526DBD: C2H2 ZF Containing ProteinsOther: Lar_restr_allev, PHD, Requiem_N

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Inferred - DPF1 (95% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DPF1 (95% AA Identity, Homo sapiens)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution