TF Info Page for POU5F1 (Homeodomain; POU)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | POU class 5 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9221] | |||||||||||||||||||||
| Entrez Summary | This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013] | |||||||||||||||||||||
| Ensembl ID: | ENSG00000204531 | |||||||||||||||||||||
| External Link: | CisBP | |||||||||||||||||||||
| Interpro | IPR000327; IPR001356; IPR009057; IPR010982; IPR013847; IPR017970; | |||||||||||||||||||||
| Protein Domain: | ENSP00000259915 | |||||||||||||||||||||
| Protein Domain: | ENSP00000389359 | |||||||||||||||||||||
| Protein Domain: | ENSP00000425083 | |||||||||||||||||||||
| Protein Domain: | ENSP00000425479 | |||||||||||||||||||||
| Protein Domain: | ENSP00000475512 | |||||||||||||||||||||
| Protein Domain: | ENSP00000475880 | |||||||||||||||||||||
| Protein Domain: | ENSP00000484778 | |||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:12615074 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity ISS - GO_REF:0000024 GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:19409607 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:16153702 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |