TF Info Page for FOXJ3 (Forkhead)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: forkhead box J3 [Source:HGNC Symbol;Acc:HGNC:29178]
Entrez Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Ensembl ID: ENSG00000198815
External Link: CisBP
Interpro IPR001766; IPR018122;
Protein Domain: ENSP00000354620
Protein Domain: ENSP00000361653
Protein Domain: ENSP00000393408
Protein Domain: ENSP00000439044
Protein Domain: ENSP00000361652
Protein Domain: ENSP00000361654
Protein Domain: ENSP00000388099
Protein Domain: ENSP00000403060
Domain:
Protein: ENSP00000354620DBD: ForkheadOther:
Protein: ENSP00000361653DBD: ForkheadOther:
Protein: ENSP00000393408DBD: ForkheadOther:
Protein: ENSP00000439044DBD: ForkheadOther:
Protein: ENSP00000361652DBD: ForkheadOther:
Protein: ENSP00000361654DBD: ForkheadOther:
Protein: ENSP00000388099DBD: ForkheadOther:
Protein: ENSP00000403060DBD: ForkheadOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2010Direct
HT-SELEXJolma2010Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
MiscHocoMocoDirect
MiscHocoMocoDirect
PBMBadis09Inferred - Foxj3 (98% AA Identity, Mus musculus)
PBMZoo_01Inferred - Foxj3 (98% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Foxj3 (98% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Foxj3 (98% AA Identity, Mus musculus)
PBMZoo_01Inferred - SPU_007644 (86% AA Identity, Strongylocentrotus purpuratus)
HT-SELEXYin2017Inferred - FOXJ2 (77% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXJ2 (77% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Foxj2 (77% AA Identity, Mus musculus)
PBMZoo_01Inferred - Foxj2 (77% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - FOXJ2 (77% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXJ2 (77% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FOXJ2 (77% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution