Complexes with CIITA and the similar protein ZXDC to regulate MHCII complex transcription (PMID: 17493635).
Description
Description:
zinc finger, X-linked, duplicated A [Source:HGNC Symbol;Acc:HGNC:13198]
Entrez Summary
This gene encodes one of two duplicated zinc finger genes on
chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the
more centromeric copy. The two genes have 98% nucleotide sequence similarity,
and the predicted proteins contain 10 tandem zinc finger motifs. [provided by
RefSeq, Nov 2009]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity IMP - PMID:17493635
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF