The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	2 Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description:	transcription factor Dp-1 [Source:HGNC Symbol;Acc:HGNC:11749]
Entrez Summary	TBA
Ensembl ID:	ENSG00000198176
External Link:	T076312_1.02
Interpro	IPR003316; IPR014889; IPR015648; ;
Protein Domain:
Protein: ENSP00000364519	DBD: E2F	Other:
Protein: ENSP00000401389	DBD: E2F	Other:
Protein: ENSP00000386145	DBD: E2F	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:8446173
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8405995
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements	Obligate_Multimer

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
Misc	HocoMoco		Direct

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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{"regions": [{"startStyle": "curved", "end": 153, "endStyle": "jagged", "aliStart": 113, "text": "E2F", "colour": "#228B22", "aliEnd": 143, "start": 112, "href": "http://pfam.xfam.org/family/PF02319.18", "type": "pfama", "display": "true", "metadata": {"end": 153, "description": "This family contains the transcription factor E2F and  its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a  homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows  that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.", "database": "PfamA", "aliStart": 113, "scoreName": "E-value", "accession": "PF02319.18", "start": 112, "score": 5.2e-08, "identifier": "E2F/DP family winged-helix DNA-binding domain", "type": "DBD", "aliEnd": 143}}], "length": 159}

{"regions": [{"startStyle": "curved", "end": 193, "endStyle": "curved", "aliStart": 113, "text": "E2F", "colour": "#228B22", "aliEnd": 193, "start": 112, "href": "http://pfam.xfam.org/family/PF02319.18", "type": "pfama", "display": "true", "metadata": {"end": 193, "description": "This family contains the transcription factor E2F and  its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a  homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows  that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.", "database": "PfamA", "aliStart": 113, "scoreName": "E-value", "accession": "PF02319.18", "start": 112, "score": 1.8e-27, "identifier": "E2F/DP family winged-helix DNA-binding domain", "type": "DBD", "aliEnd": 193}}, {"startStyle": "curved", "end": 236, "endStyle": "jagged", "aliStart": 200, "text": "DP", "colour": "#2cb42c", "aliEnd": 236, "start": 200, "href": "http://pfam.xfam.org/family/PF08781.8", "type": "pfama", "display": "true", "metadata": {"end": 236, "description": "DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression", "database": "PfamA", "aliStart": 200, "scoreName": "E-value", "accession": "PF08781.8", "start": 200, "score": 5.9e-09, "identifier": "Transcription factor DP", "type": "DBD", "aliEnd": 236}}], "length": 236}

TF Info Page for TFDP1 (E2F)