Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain
Description
Description:
zinc finger protein 251 [Source:HGNC Symbol;Acc:HGNC:13045]
Entrez Summary
Predicted to enable DNA-binding transcription factor activity, RNA
polymerase II-specific and RNA polymerase II cis-regulatory region
sequence-specific DNA binding activity. Predicted to be involved in
regulation of transcription by RNA polymerase II. Predicted to act upstream
of or within hematopoietic stem cell homeostasis. Predicted to be active in
nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF