The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	TEA domain transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11717]
Entrez Summary	TBA
Ensembl ID:	ENSG00000197905
External Link:	T151689_1.02
Interpro	IPR000818; IPR016361; IPR027255; ;
Protein Domain:
Protein: ENSP00000351184	DBD: TEA	Other:
Protein: ENSP00000352926	DBD: TEA	Other:
Protein: ENSP00000380311	DBD: TEA	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:8631987
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:18579750, PMID:19324877
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
HT-SELEX	Yin2017		Inferred - TEAD1 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - TEAD1 (78% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - TEAD1 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TEAD1 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TEAD1 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TEAD1 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TEAD1 (78% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - TEAD1 (78% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TEAD3 (76% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - TEAD3 (76% AA Identity, Homo sapiens)
PBM	TF_Evolution	Unpublished Data	Inferred - ENSTNIG00000008857_CONSTRUCT (73% AA Identity, PBM CONSTRUCTS)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "jagged", "end": 114, "endStyle": "jagged", "aliStart": 37, "text": "TEA", "colour": "#009900", "aliEnd": 105, "start": 31, "href": "http://pfam.xfam.org/family/PF01285.16", "type": "pfama", "display": "true", "metadata": {"end": 114, "description": "Transcriptional enhancer activators are nuclear proteins that contain a TEA/ATTSdomain, a DNA-binding region of 66-68 amino acids. The TEA/ATTS domain is found in the N-termini of certain gene regulatory proteins, such as the Simian virus 40 (SV40) enhancer factor TEF-1, yeast trans-acting factor TEC-1 (which is required for TY1 enhancer activity), and the Aspergillus abaA regulatory gene product. SV40 and retroviral enhancers, and those to which TEF-1, TEC-1 and abaA proteins bind, contain GT-IIC sites: the TEA/ATTS domain may therefore recognise and bind such sites. Secondary structure predictions suggest the presence of 3 helices, but have not confirmed the presence of the helix-turn-helix motif characteristic of many DNA-binding proteins: DNA-binding may therefore be effected by a different mechanism [PUBMED:2070413].", "database": "PfamA", "aliStart": 37, "scoreName": "E-value", "accession": "PF01285.16", "start": 31, "score": 7.6e-27, "identifier": "TEA/ATTS domain family", "type": "DBD", "aliEnd": 105}}], "length": 392}

{"regions": [{"startStyle": "jagged", "end": 155, "endStyle": "jagged", "aliStart": 37, "text": "TEA", "colour": "#009900", "aliEnd": 106, "start": 31, "href": "http://pfam.xfam.org/family/PF01285.16", "type": "pfama", "display": "true", "metadata": {"end": 155, "description": "Transcriptional enhancer activators are nuclear proteins that contain a TEA/ATTSdomain, a DNA-binding region of 66-68 amino acids. The TEA/ATTS domain is found in the N-termini of certain gene regulatory proteins, such as the Simian virus 40 (SV40) enhancer factor TEF-1, yeast trans-acting factor TEC-1 (which is required for TY1 enhancer activity), and the Aspergillus abaA regulatory gene product. SV40 and retroviral enhancers, and those to which TEF-1, TEC-1 and abaA proteins bind, contain GT-IIC sites: the TEA/ATTS domain may therefore recognise and bind such sites. Secondary structure predictions suggest the presence of 3 helices, but have not confirmed the presence of the helix-turn-helix motif characteristic of many DNA-binding proteins: DNA-binding may therefore be effected by a different mechanism [PUBMED:2070413].", "database": "PfamA", "aliStart": 37, "scoreName": "E-value", "accession": "PF01285.16", "start": 31, "score": 5.4e-27, "identifier": "TEA/ATTS domain family", "type": "DBD", "aliEnd": 106}}], "length": 435}

TF Info Page for TEAD4 (TEA)