TF Info Page for ZNF655 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains

Description

Description: zinc finger protein 655 [Source:HGNC Symbol;Acc:HGNC:30899]
Entrez Summary This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000197343
External Link: CisBP
Interpro IPR001909; IPR007087; IPR015880; ;
Protein Domain: ENSP00000252713
Protein Domain: ENSP00000322363
Protein Domain: ENSP00000377718
Protein Domain: ENSP00000350530
Protein Domain: ENSP00000389260
Protein Domain: ENSP00000393876
Protein Domain: ENSP00000396396
Protein Domain: ENSP00000398872
Protein Domain: ENSP00000419135
Protein Domain: ENSP00000392980
Domain:
Protein: ENSP00000252713DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000322363DBD: C2H2 ZF Containing ProteinsOther: KRAB
Protein: ENSP00000377718DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000350530DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000389260DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000393876DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000396396DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000398872DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000419135DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000392980DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution