MAF bZIP transcription factor G [Source:HGNC Symbol;Acc:HGNC:6781]
Entrez Summary
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Globin gene expression is regulated through nuclear factor
erythroid-2 (NFE2) elements located in enhancer-like locus control regions
positioned many kb upstream of alpha- and beta-gene clusters (summarized by
Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a
heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877;
MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM
601490). Both subunits are members of the activator protein-1-like
superfamily of basic leucine zipper (bZIP) proteins (see MIM
165160).[supplied by OMIM, Mar 2010]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:9286713
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF