Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer 100 perc ID - in vitro


Description: AT-rich interaction domain 5A [Source:HGNC Symbol;Acc:HGNC:17361]
Entrez Summary Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]
Ensembl ID: ENSG00000196843
External Link: CisBP
Interpro IPR001606; ;
Protein Domain: ENSP00000350078
Protein Domain: ENSP00000400785
Protein: ENSP00000350078DBD: ARID/BRIGHTOther:
Protein: ENSP00000400785DBD: ARID/BRIGHTOther:

Previous Annotations

Source Annotation
TF-CAT classification Indeterminate - There is no evidence for or against this genes role as a TF___
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMBadis09Inferred - Arid5a (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - Arid5a (100% AA Identity, Rattus norvegicus)
PBMZoo_01Inferred - Arid5b (72% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ARID5B (72% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ARID5B (72% AA Identity, Homo sapiens)
PBMZoo_01Inferred - arid5b (64% AA Identity, Danio rerio)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution