The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	estrogen related receptor gamma [Source:HGNC Symbol;Acc:HGNC:3474]
Entrez Summary	TBA
Ensembl ID:	ENSG00000196482
External Link:
Interpro	IPR000536; IPR001628; IPR001723; IPR003078; IPR008946; IPR024178; IPR027289; ;
Protein Domain:
Protein: ENSP00000352077	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000353108	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000354584	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000355904	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000355905	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000355907	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000386171	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000419514	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000419155	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000419594	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000417374	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000481528	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000418629	DBD: Nuclear Hormone Receptor	Other: Hormone_recep
Protein: ENSP00000417900	DBD: Nuclear Hormone Receptor	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:15149736
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info	GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IEA - GO_REF:0000019 GO:0003708 retinoic acid receptor activity IEA - GO_REF:0000002
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
HT-SELEX	Yin2017		Inferred - ESRRB (100% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ESRRB (100% AA Identity, Homo sapiens)
PBM	DREAM_contest		Inferred - Esrrg (100% AA Identity, Mus musculus)
SELEX	JASPAR		Inferred - ESRRB (100% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESRRB (100% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESRRB (100% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ESRRB (100% AA Identity, Homo sapiens)
ChIP-seq	hmCHIP		Inferred - Esrrb (98% AA Identity, Mus musculus)
PBM	DREAM_contest		Inferred - Esrrb (97% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - ESRRA (91% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ESRRA (91% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ESRRA (91% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ESRRA (91% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Esrra (91% AA Identity, Mus musculus)
ChIP-seq	ENCODE		Inferred - ESRRA (91% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - ESRRA (91% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESRRA (91% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESRRA (91% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESRRA (91% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ESRRA (91% AA Identity, Homo sapiens)
SELEX	JASPAR		Inferred - Esrra (91% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - ESRRA (91% AA Identity, Homo sapiens)
HT-SELEX	Nitta2015		Inferred - ERR (87% AA Identity, Drosophila melanogaster)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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{"regions": [{"startStyle": "curved", "end": 200, "endStyle": "curved", "aliStart": 132, "text": "NHR", "colour": "#2cb42c", "aliEnd": 200, "start": 131, "href": "http://pfam.xfam.org/family/PF00105.16", "type": "pfama", "display": "true", "metadata": {"end": 200, "description": "In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.", "database": "PfamA", "aliStart": 132, "scoreName": "E-value", "accession": "PF00105.16", "start": 131, "score": 6.5e-31, "identifier": "Zinc finger, C4 type (two domains)", "type": "DBD", "aliEnd": 200}}, {"startStyle": "straight", "end": 453, "endStyle": "straight", "aliStart": 278, "text": "Hormone_recep", "colour": "#9999ff", "aliEnd": 452, "start": 267, "href": "http://pfam.xfam.org/family/PF00104.28", "type": "pfama", "display": "true", "metadata": {"end": 453, "description": "This all helical domain is involved in binding the hormone in these receptors.", "database": "PfamA", "aliStart": 278, "scoreName": "E-value", "accession": "PF00104.28", "start": 267, "score": 7.5e-33, "identifier": "Ligand-binding domain of nuclear hormone receptor", "type": "DBD", "aliEnd": 452}}], "length": 471}

{"regions": [{"startStyle": "curved", "end": 195, "endStyle": "curved", "aliStart": 127, "text": "NHR", "colour": "#2cb42c", "aliEnd": 195, "start": 126, "href": "http://pfam.xfam.org/family/PF00105.16", "type": "pfama", "display": "true", "metadata": {"end": 195, "description": "In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.", "database": "PfamA", "aliStart": 127, "scoreName": "E-value", "accession": "PF00105.16", "start": 126, "score": 6e-31, "identifier": "Zinc finger, C4 type (two domains)", "type": "DBD", "aliEnd": 195}}, {"startStyle": "straight", "end": 441, "endStyle": "straight", "aliStart": 266, "text": "Hormone_recep", "colour": "#9999ff", "aliEnd": 440, "start": 255, "href": "http://pfam.xfam.org/family/PF00104.28", "type": "pfama", "display": "true", "metadata": {"end": 441, "description": "This all helical domain is involved in binding the hormone in these receptors.", "database": "PfamA", "aliStart": 266, "scoreName": "E-value", "accession": "PF00104.28", "start": 255, "score": 6.6e-33, "identifier": "Ligand-binding domain of nuclear hormone receptor", "type": "DBD", "aliEnd": 440}}], "length": 459}

{"regions": [{"startStyle": "curved", "end": 172, "endStyle": "curved", "aliStart": 104, "text": "NHR", "colour": "#2cb42c", "aliEnd": 172, "start": 103, "href": "http://pfam.xfam.org/family/PF00105.16", "type": "pfama", "display": "true", "metadata": {"end": 172, "description": "In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.", "database": "PfamA", "aliStart": 104, "scoreName": "E-value", "accession": "PF00105.16", "start": 103, "score": 4.8e-31, "identifier": "Zinc finger, C4 type (two domains)", "type": "DBD", "aliEnd": 172}}, {"startStyle": "straight", "end": 354, "endStyle": "jagged", "aliStart": 243, "text": "Hormone_recep", "colour": "#9999ff", "aliEnd": 353, "start": 232, "href": "http://pfam.xfam.org/family/PF00104.28", "type": "pfama", "display": "true", "metadata": {"end": 354, "description": "This all helical domain is involved in binding the hormone in these receptors.", "database": "PfamA", "aliStart": 243, "scoreName": "E-value", "accession": "PF00104.28", "start": 232, "score": 3.1999999999999998e-21, "identifier": "Ligand-binding domain of nuclear hormone receptor", "type": "DBD", "aliEnd": 353}}], "length": 354}

{"regions": [{"startStyle": "curved", "end": 153, "endStyle": "jagged", "aliStart": 104, "text": "NHR", "colour": "#2cb42c", "aliEnd": 136, "start": 103, "href": "http://pfam.xfam.org/family/PF00105.16", "type": "pfama", "display": "true", "metadata": {"end": 153, "description": "In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.", "database": "PfamA", "aliStart": 104, "scoreName": "E-value", "accession": "PF00105.16", "start": 103, "score": 9.6e-15, "identifier": "Zinc finger, C4 type (two domains)", "type": "DBD", "aliEnd": 136}}, {"startStyle": "straight", "end": 379, "endStyle": "straight", "aliStart": 204, "text": "Hormone_recep", "colour": "#9999ff", "aliEnd": 378, "start": 193, "href": "http://pfam.xfam.org/family/PF00104.28", "type": "pfama", "display": "true", "metadata": {"end": 379, "description": "This all helical domain is involved in binding the hormone in these receptors.", "database": "PfamA", "aliStart": 204, "scoreName": "E-value", "accession": "PF00104.28", "start": 193, "score": 5.5e-33, "identifier": "Ligand-binding domain of nuclear hormone receptor", "type": "DBD", "aliEnd": 378}}], "length": 397}

TF Info Page for ESRRG (Nuclear receptor)