TF Info Page for ESRRG (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | estrogen related receptor gamma [Source:HGNC Symbol;Acc:HGNC:3474] | ||||||||||||||||||||||||||||||||||||||||||
| Entrez Summary | This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011] | ||||||||||||||||||||||||||||||||||||||||||
| Ensembl ID: | ENSG00000196482 | ||||||||||||||||||||||||||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||||||||||||||||||||||||||
| Interpro | IPR000536; IPR001628; IPR001723; IPR003078; IPR008946; IPR024178; IPR027289; ; | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000352077 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000353108 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000354584 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000355904 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000355905 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000355907 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000386171 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000419514 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000419155 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000419594 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000417374 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000481528 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000418629 | ||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000417900 | ||||||||||||||||||||||||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:15149736 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info |
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IEA - GO_REF:0000019 GO:0003708 retinoic acid receptor activity IEA - GO_REF:0000002 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |