The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)

Description

Description:

zinc finger protein 124 [Source:HGNC Symbol;Acc:HGNC:12907]

Entrez Summary

This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]

Ensembl ID:

ENSG00000196418

External Link:

CisBP

Interpro

IPR001909; IPR007087; IPR015880; ;

Protein Domain:

ENSP00000340749

Protein Domain:

ENSP00000440365

Protein Domain:

ENSP00000462445

Protein Domain:

ENSP00000463191

Domain:

Protein: ENSP00000340749	DBD: C2H2 ZF Containing Proteins	Other: KRAB
Protein: ENSP00000440365	DBD: C2H2 ZF Containing Proteins	Other: KRAB, zf-H2C2_2
Protein: ENSP00000462445	DBD: C2H2 ZF Containing Proteins	Other: KRAB
Protein: ENSP00000463191	DBD: C2H2 ZF Containing Proteins	Other: KRAB

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	b
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
RCADE	Imbeault2017		Direct - consistent with recognition code (RCADE)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 110, "endStyle": "curved", "aliStart": 88, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 110, "start": 88, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 110, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 88, "scoreName": "E-value", "accession": "PF00096.24", "start": 88, "score": 1.8999999999999998e-32, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 110}}, {"startStyle": "curved", "end": 138, "endStyle": "curved", "aliStart": 116, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 138, "start": 116, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 138, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 116, "scoreName": "E-value", "accession": "PF00096.24", "start": 116, "score": 1.8999999999999998e-32, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 138}}, {"startStyle": "curved", "end": 166, "endStyle": "curved", "aliStart": 144, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 166, "start": 144, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 166, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 144, "scoreName": "E-value", "accession": "PF00096.24", "start": 144, "score": 1.8999999999999998e-32, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 166}}, {"startStyle": "curved", "end": 194, "endStyle": "curved", "aliStart": 172, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 194, "start": 172, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 194, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 172, "scoreName": "E-value", "accession": "PF00096.24", "start": 172, "score": 1.8999999999999998e-32, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 194}}, {"startStyle": "curved", "end": 222, "endStyle": "curved", "aliStart": 200, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 222, "start": 200, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 222, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 200, "scoreName": "E-value", "accession": "PF00096.24", "start": 200, "score": 1.8999999999999998e-32, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 222}}, {"startStyle": "curved", "end": 250, "endStyle": "curved", "aliStart": 228, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 250, "start": 228, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 250, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 228, "scoreName": "E-value", "accession": "PF00096.24", "start": 228, "score": 1.8999999999999998e-32, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 250}}, {"startStyle": "curved", "end": 278, "endStyle": "curved", "aliStart": 256, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 278, "start": 256, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 278, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 256, "scoreName": "E-value", "accession": "PF00096.24", "start": 256, "score": 1.8999999999999998e-32, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 278}}, {"startStyle": "straight", "end": 53, "endStyle": "straight", "aliStart": 12, "text": "KRAB", "colour": "#9999ff", "aliEnd": 53, "start": 12, "href": "http://pfam.xfam.org/family/PF01352.25", "type": "pfama", "display": "true", "metadata": {"end": 53, "description": "The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].", "database": "PfamA", "aliStart": 12, "scoreName": "E-value", "accession": "PF01352.25", "start": 12, "score": 6.5e-26, "identifier": "KRAB box", "type": "DBD", "aliEnd": 53}}], "length": 290}

{"regions": [{"startStyle": "jagged", "end": 144, "endStyle": "curved", "aliStart": 124, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 144, "start": 122, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 144, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 124, "scoreName": "E-value", "accession": "PF00096.24", "start": 122, "score": 6.6e-31, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 144}}, {"startStyle": "curved", "end": 172, "endStyle": "curved", "aliStart": 150, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 172, "start": 150, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 172, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 150, "scoreName": "E-value", "accession": "PF00096.24", "start": 150, "score": 6.6e-31, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 172}}, {"startStyle": "curved", "end": 200, "endStyle": "curved", "aliStart": 178, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 200, "start": 178, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 200, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 178, "scoreName": "E-value", "accession": "PF00096.24", "start": 178, "score": 6.6e-31, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 200}}, {"startStyle": "curved", "end": 228, "endStyle": "curved", "aliStart": 206, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 228, "start": 206, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 228, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 206, "scoreName": "E-value", "accession": "PF00096.24", "start": 206, "score": 6.6e-31, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 228}}, {"startStyle": "curved", "end": 256, "endStyle": "curved", "aliStart": 234, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 256, "start": 234, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 256, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 234, "scoreName": "E-value", "accession": "PF00096.24", "start": 234, "score": 6.6e-31, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 256}}, {"startStyle": "curved", "end": 284, "endStyle": "curved", "aliStart": 262, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 284, "start": 262, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 284, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 262, "scoreName": "E-value", "accession": "PF00096.24", "start": 262, "score": 6.6e-31, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 284}}, {"startStyle": "curved", "end": 312, "endStyle": "curved", "aliStart": 290, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 312, "start": 290, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 312, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 290, "scoreName": "E-value", "accession": "PF00096.24", "start": 290, "score": 6.6e-31, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 312}}, {"startStyle": "curved", "end": 340, "endStyle": "curved", "aliStart": 318, "text": "zfC2H2", "colour": "#228B22", "aliEnd": 340, "start": 318, "href": "http://pfam.xfam.org/family/PF00096.24", "type": "pfama", "display": "true", "metadata": {"end": 340, "description": "The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].", "database": "PfamA", "aliStart": 318, "scoreName": "E-value", "accession": "PF00096.24", "start": 318, "score": 6.6e-31, "identifier": "Zinc finger, C2H2 type", "type": "DBD", "aliEnd": 340}}, {"startStyle": "jagged", "end": 105, "endStyle": "straight", "aliStart": 73, "text": "zf-H2C2_2", "colour": "#9999ff", "aliEnd": 92, "start": 72, "href": "http://pfam.xfam.org/family/PF13465.4", "type": "pfama", "display": "true", "metadata": {"end": 105, "description": NaN, "database": "PfamA", "aliStart": 73, "scoreName": "E-value", "accession": "PF13465.4", "start": 72, "score": 4.1999999999999996e-64, "identifier": "Zinc-finger double domain", "type": "DBD", "aliEnd": 92}}, {"startStyle": "straight", "end": 53, "endStyle": "straight", "aliStart": 12, "text": "KRAB", "colour": "#9999ff", "aliEnd": 53, "start": 12, "href": "http://pfam.xfam.org/family/PF01352.25", "type": "pfama", "display": "true", "metadata": {"end": 53, "description": "The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].", "database": "PfamA", "aliStart": 12, "scoreName": "E-value", "accession": "PF01352.25", "start": 12, "score": 8.500000000000001e-26, "identifier": "KRAB box", "type": "DBD", "aliEnd": 53}}], "length": 352}

{"regions": [{"startStyle": "straight", "end": 53, "endStyle": "straight", "aliStart": 12, "text": "KRAB", "colour": "#9999ff", "aliEnd": 53, "start": 12, "href": "http://pfam.xfam.org/family/PF01352.25", "type": "pfama", "display": "true", "metadata": {"end": 53, "description": "The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].", "database": "PfamA", "aliStart": 12, "scoreName": "E-value", "accession": "PF01352.25", "start": 12, "score": 5.1999999999999996e-27, "identifier": "KRAB box", "type": "DBD", "aliEnd": 53}}], "length": 74}

{"regions": [{"startStyle": "straight", "end": 53, "endStyle": "straight", "aliStart": 12, "text": "KRAB", "colour": "#9999ff", "aliEnd": 53, "start": 12, "href": "http://pfam.xfam.org/family/PF01352.25", "type": "pfama", "display": "true", "metadata": {"end": 53, "description": "The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].", "database": "PfamA", "aliStart": 12, "scoreName": "E-value", "accession": "PF01352.25", "start": 12, "score": 5.7999999999999994e-27, "identifier": "KRAB box", "type": "DBD", "aliEnd": 53}}], "length": 78}

TF Info Page for ZNF124 (C2H2 ZF(KRAB))

Conclusion

Description

Previous Annotations

DNA-Binding

Published Motif Data

Structure

Experimental History

External Contribution