TF Info Page for LCOR (Pipsqueak)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer 100 perc ID - in vitro


Description: ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503]
Entrez Summary LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Ensembl ID: ENSG00000196233
External Link: CisBP
Interpro IPR007889; IPR009057;
Protein Domain: ENSP00000360138
Protein Domain: ENSP00000360144
Protein Domain: ENSP00000443431
Protein Domain: ENSP00000348298
Protein Domain: ENSP00000286067
Protein Domain: ENSP00000490116
Protein: ENSP00000360138DBD: PipsqueakOther:
Protein: ENSP00000360144DBD: PipsqueakOther:
Protein: ENSP00000443431DBD: PipsqueakOther:
Protein: ENSP00000348298DBD: PipsqueakOther:
Protein: ENSP00000286067DBD: PipsqueakOther: DUF4553
Protein: ENSP00000490116DBD: PipsqueakOther: DUF4553

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMZoo_01Inferred - LCOR (100% AA Identity, Meleagris gallopavo)
PBMZoo_01Inferred - LCOR (95% AA Identity, Anolis carolinensis)
PBMZoo_01Inferred - XP_012821380.1 (95% AA Identity, Xenopus tropicalis)
PBMZoo_01Inferred - ENSORLG00000000044 (91% AA Identity, Oryzias latipes)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution