TF Info Page for PAX5 (Paired box)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: paired box 5 [Source:HGNC Symbol;Acc:HGNC:8619]
Entrez Summary This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Ensembl ID: ENSG00000196092
External Link: CisBP
Interpro IPR001523; IPR009057; IPR022130; ;
Protein Domain: ENSP00000350844
Protein Domain: ENSP00000367078
Protein Domain: ENSP00000367083
Protein Domain: ENSP00000367084
Protein Domain: ENSP00000412188
Protein Domain: ENSP00000404687
Protein Domain: ENSP00000429291
Protein Domain: ENSP00000430773
Protein Domain: ENSP00000429359
Protein Domain: ENSP00000428670
Protein Domain: ENSP00000429197
Protein Domain: ENSP00000429637
Protein Domain: ENSP00000429404
Protein: ENSP00000350844DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000367078DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000367083DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000367084DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000412188DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000404687DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000429291DBD: Paired BoxOther:
Protein: ENSP00000430773DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000429359DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000428670DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000429197DBD: Paired BoxOther: Pax2_C
Protein: ENSP00000429637DBD: Paired BoxOther:
Protein: ENSP00000429404DBD: Paired BoxOther: Pax2_C

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
PBMTF_EvolutionUnpublished DataInferred - Pax5 (100% AA Identity, Gallus gallus)
PBMZoo_01Inferred - pax2 (97% AA Identity, Xenopus tropicalis)
PBMZoo_01Inferred - pax2b (96% AA Identity, Danio rerio)
HT-SELEXYin2017Inferred - PAX8 (93% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PAX8 (93% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PAX8 (93% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - PAX8 (93% AA Identity, Homo sapiens)
MiscHocoMocoInferred - PAX8 (93% AA Identity, Homo sapiens)
MiscHOMERInferred - Pax8 (93% AA Identity, Rattus norvegicus)
HT-SELEXNitta2015Inferred - sv (86% AA Identity, Drosophila melanogaster)
PBMTF_EvolutionUnpublished DataInferred - sv (86% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - egl-38 (71% AA Identity, Caenorhabditis elegans)
PBMCEPDInferred - pax-2 (71% AA Identity, Caenorhabditis elegans)


Structure PDB 1K78

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution