TF Info Page for LIN54 (TCR/CxC)


Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro In the structure (PDB: 5FD3), the protein contacts DNA, although it only contacts the backbone except for one tyrosine residue


Description: lin-54 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:25397]
Entrez Summary LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
Ensembl ID: ENSG00000189308
External Link: CisBP
Interpro IPR005172; ;
Protein Domain: ENSP00000341947
Protein Domain: ENSP00000398265
Protein Domain: ENSP00000407139
Protein Domain: ENSP00000423475
Protein Domain: ENSP00000421045
Protein: ENSP00000341947DBD: CxCOther:
Protein: ENSP00000398265DBD: CxCOther:
Protein: ENSP00000407139DBD: CxCOther:
Protein: ENSP00000423475DBD: CxCOther:
Protein: ENSP00000421045DBD: CxCOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
3a, decent circumstantial evidence for its role as
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMZoo_01Inferred - LIN54 (98% AA Identity, Gallus gallus)
PBMZoo_01Inferred - LIN54 (94% AA Identity, Tarsius syrichta)
PBMZoo_01Inferred - lin54 (92% AA Identity, Danio rerio)
PBMZoo_01Inferred - SPU_025306 (88% AA Identity, Strongylocentrotus purpuratus)
PBMTF_EvolutionUnpublished DataInferred - NEMVEDRAFT_v1g111410 (84% AA Identity, Nematostella vectensis)
PBMTF_EvolutionUnpublished DataInferred - XP_002124866.1 (82% AA Identity, Ciona intestinalis)
PBMZoo_01Inferred - BGIBMGA008956 (81% AA Identity, Bombyx mori)
PBMZoo_01Inferred - GE12548 (80% AA Identity, Drosophila yakuba)


Structure PDB 5FD3

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution