TF Info Page for SP6 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: Sp6 transcription factor [Source:HGNC Symbol;Acc:HGNC:14530]
Entrez Summary SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
Ensembl ID: ENSG00000189120
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000340799
Protein Domain: ENSP00000438209
Domain:
Protein: ENSP00000340799DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000438209DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification Indeterminate - There is no evidence for or against this genes role as a TF___
PMIDS:0
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXNitta2015Inferred - Sp1 (86% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - SP8 (84% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SP8 (84% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - SP9 (84% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SP9 (84% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP5 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - SP3 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SP3 (80% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP3 (80% AA Identity, Homo sapiens)
MiscHocoMocoInferred - SP3 (80% AA Identity, Homo sapiens)
PBMBadis09Inferred - Sp4 (78% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - Sp4 (78% AA Identity, Mus musculus)
PBMZoo_01Inferred - Sp4 (78% AA Identity, Mus musculus)
ChIP-seqSchmitges2016Inferred - SP4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP4 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP7 (78% AA Identity, Homo sapiens)
MiscHocoMocoInferred - SP4 (78% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Sp1 (75% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - SP1 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SP1 (73% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - SP2 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SP2 (73% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - SP1 (73% AA Identity, Homo sapiens)
ChIP-seqSchmitges2016Inferred - SP1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP1 (73% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - SP2 (73% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - SP2 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP2 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP2 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP2 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP2 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SP2 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - SP1 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - SP1 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - SP2 (73% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution