TF Info Page for SP6 (C2H2 ZF(non-KRAB))
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Inferred motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | Sp6 transcription factor [Source:HGNC Symbol;Acc:HGNC:14530] | ||||||
| Entrez Summary | SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008] | ||||||
| Ensembl ID: | ENSG00000189120 | ||||||
| External Link: | CisBP | ||||||
| Interpro | IPR007087; IPR015880; | ||||||
| Protein Domain: | ENSP00000340799 | ||||||
| Protein Domain: | ENSP00000438209 | ||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
Indeterminate - There is no evidence for or against this genes role as a TF___ PMIDS:0 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a2, Orthologous HQ evidence |
| TF has conditional DNA-binding requirements |