The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif

Description

Description:	AT-rich interaction domain 2 [Source:HGNC Symbol;Acc:HGNC:18037]
Entrez Summary	TBA
Ensembl ID:	ENSG00000189079
External Link:	T008430_1.02
Interpro	IPR001606; IPR003150; IPR007087; IPR016024;
Protein Domain:
Protein: ENSP00000335044	DBD: ARID/BRIGHT, RFX	Other:
Protein: ENSP00000415650	DBD: ARID/BRIGHT, RFX	Other:
Protein: ENSP00000397307	DBD: ARID/BRIGHT, RFX	Other:
Protein: ENSP00000388357	DBD: ARID/BRIGHT, RFX	Other: FOXP-CC
Protein: ENSP00000481488	DBD: ARID/BRIGHT, RFX	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_Transcription Factor Binding tf co-factor binding_Co-activation_ PMIDS:16782067
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	x
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 101, "endStyle": "curved", "aliStart": 18, "text": "ARID", "colour": "#2cb42c", "aliEnd": 101, "start": 15, "href": "http://pfam.xfam.org/family/PF01388.19", "type": "pfama", "display": "true", "metadata": {"end": 101, "description": "This domain is know as ARID for AT-Rich Interaction Domain [1], and also known as the BRIGHT domain [3].", "database": "PfamA", "aliStart": 18, "scoreName": "E-value", "accession": "PF01388.19", "start": 15, "score": 8.6e-25, "identifier": "ARID/BRIGHT DNA binding domain", "type": "DBD", "aliEnd": 101}}, {"startStyle": "curved", "end": 603, "endStyle": "curved", "aliStart": 522, "text": "RFX", "colour": "#2cb42c", "aliEnd": 602, "start": 521, "href": "http://pfam.xfam.org/family/PF02257.13", "type": "pfama", "display": "true", "metadata": {"end": 603, "description": "RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].", "database": "PfamA", "aliStart": 522, "scoreName": "E-value", "accession": "PF02257.13", "start": 521, "score": 4.0000000000000004e-24, "identifier": "RFX DNA-binding domain", "type": "DBD", "aliEnd": 602}}], "length": 1836}

{"regions": [{"startStyle": "straight", "end": 272, "endStyle": "jagged", "aliStart": 241, "text": "FOXP-CC", "colour": "#9999ff", "aliEnd": 267, "start": 238, "href": "http://pfam.xfam.org/family/PF16159.3", "type": "pfama", "display": "true", "metadata": {"end": 272, "description": "This domain, approximately 60-70 residues in length, is  mainly found in Forkhead box proteins in various Mammalia  species [1]. It is a coiled-coil domain, which modulates  the dimeric associations of FOXP transcription factors.  Several key disease mutations, for instance those found in  the IPEX syndrome are located in this domain [2]", "database": "PfamA", "aliStart": 241, "scoreName": "E-value", "accession": "PF16159.3", "start": 238, "score": 0.00013000000000000002, "identifier": "FOXP coiled-coil domain", "type": "DBD", "aliEnd": 267}}, {"startStyle": "straight", "end": 312, "endStyle": "jagged", "aliStart": 273, "text": "FOXP-CC", "colour": "#9999ff", "aliEnd": 306, "start": 270, "href": "http://pfam.xfam.org/family/PF16159.3", "type": "pfama", "display": "true", "metadata": {"end": 312, "description": "This domain, approximately 60-70 residues in length, is  mainly found in Forkhead box proteins in various Mammalia  species [1]. It is a coiled-coil domain, which modulates  the dimeric associations of FOXP transcription factors.  Several key disease mutations, for instance those found in  the IPEX syndrome are located in this domain [2]", "database": "PfamA", "aliStart": 273, "scoreName": "E-value", "accession": "PF16159.3", "start": 270, "score": 0.00013000000000000002, "identifier": "FOXP coiled-coil domain", "type": "DBD", "aliEnd": 306}}], "length": 402}

TF Info Page for ARID2 (ARID/BRIGHT; RFX)