The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	SKI family transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:21326]
Entrez Summary	TBA
Ensembl ID:	ENSG00000188779
External Link:
Interpro	IPR003380; IPR009061; IPR010919; IPR014890;
Protein Domain:
Protein: ENSP00000343200	DBD: Other	Other: Ski_Sno, c-SKI_SMAD_bind
Protein: ENSP00000369374	DBD: Other	Other: Ski_Sno, c-SKI_SMAD_bind
Protein: ENSP00000452361	DBD: Other	Other: Ski_Sno, c-SKI_SMAD_bind
Protein: ENSP00000451193	DBD: Other	Other: Ski_Sno, c-SKI_SMAD_bind

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	No
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "jagged", "end": 354, "endStyle": "straight", "aliStart": 258, "text": "Ski_Sno", "colour": "#9999ff", "aliEnd": 353, "start": 247, "href": "http://pfam.xfam.org/family/PF02437.15", "type": "pfama", "display": "true", "metadata": {"end": 354, "description": "This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].", "database": "PfamA", "aliStart": 258, "scoreName": "E-value", "accession": "PF02437.15", "start": 247, "score": 1.1e-38, "identifier": "SKI/SNO/DAC family", "type": "DBD", "aliEnd": 353}}, {"startStyle": "straight", "end": 454, "endStyle": "straight", "aliStart": 366, "text": "c-SKI_SMAD_bind", "colour": "#9999ff", "aliEnd": 452, "start": 366, "href": "http://pfam.xfam.org/family/PF08782.8", "type": "pfama", "display": "true", "metadata": {"end": 454, "description": "c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]", "database": "PfamA", "aliStart": 366, "scoreName": "E-value", "accession": "PF08782.8", "start": 366, "score": 8.7e-29, "identifier": "c-SKI Smad4 binding domain", "type": "DBD", "aliEnd": 452}}], "length": 869}

{"regions": [{"startStyle": "jagged", "end": 168, "endStyle": "straight", "aliStart": 72, "text": "Ski_Sno", "colour": "#9999ff", "aliEnd": 167, "start": 61, "href": "http://pfam.xfam.org/family/PF02437.15", "type": "pfama", "display": "true", "metadata": {"end": 168, "description": "This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].", "database": "PfamA", "aliStart": 72, "scoreName": "E-value", "accession": "PF02437.15", "start": 61, "score": 1.3e-38, "identifier": "SKI/SNO/DAC family", "type": "DBD", "aliEnd": 167}}, {"startStyle": "straight", "end": 271, "endStyle": "straight", "aliStart": 180, "text": "c-SKI_SMAD_bind", "colour": "#9999ff", "aliEnd": 271, "start": 180, "href": "http://pfam.xfam.org/family/PF08782.8", "type": "pfama", "display": "true", "metadata": {"end": 271, "description": "c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]", "database": "PfamA", "aliStart": 180, "scoreName": "E-value", "accession": "PF08782.8", "start": 180, "score": 5.2e-31, "identifier": "c-SKI Smad4 binding domain", "type": "DBD", "aliEnd": 271}}], "length": 966}

{"regions": [{"startStyle": "jagged", "end": 140, "endStyle": "straight", "aliStart": 44, "text": "Ski_Sno", "colour": "#9999ff", "aliEnd": 139, "start": 33, "href": "http://pfam.xfam.org/family/PF02437.15", "type": "pfama", "display": "true", "metadata": {"end": 140, "description": "This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].", "database": "PfamA", "aliStart": 44, "scoreName": "E-value", "accession": "PF02437.15", "start": 33, "score": 1.3e-38, "identifier": "SKI/SNO/DAC family", "type": "DBD", "aliEnd": 139}}, {"startStyle": "straight", "end": 243, "endStyle": "straight", "aliStart": 152, "text": "c-SKI_SMAD_bind", "colour": "#9999ff", "aliEnd": 243, "start": 152, "href": "http://pfam.xfam.org/family/PF08782.8", "type": "pfama", "display": "true", "metadata": {"end": 243, "description": "c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]", "database": "PfamA", "aliStart": 152, "scoreName": "E-value", "accession": "PF08782.8", "start": 152, "score": 5e-31, "identifier": "c-SKI Smad4 binding domain", "type": "DBD", "aliEnd": 243}}], "length": 938}

{"regions": [{"startStyle": "jagged", "end": 129, "endStyle": "straight", "aliStart": 33, "text": "Ski_Sno", "colour": "#9999ff", "aliEnd": 128, "start": 22, "href": "http://pfam.xfam.org/family/PF02437.15", "type": "pfama", "display": "true", "metadata": {"end": 129, "description": "This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].", "database": "PfamA", "aliStart": 33, "scoreName": "E-value", "accession": "PF02437.15", "start": 22, "score": 1.3e-38, "identifier": "SKI/SNO/DAC family", "type": "DBD", "aliEnd": 128}}, {"startStyle": "straight", "end": 232, "endStyle": "straight", "aliStart": 141, "text": "c-SKI_SMAD_bind", "colour": "#9999ff", "aliEnd": 232, "start": 141, "href": "http://pfam.xfam.org/family/PF08782.8", "type": "pfama", "display": "true", "metadata": {"end": 232, "description": "c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]", "database": "PfamA", "aliStart": 141, "scoreName": "E-value", "accession": "PF08782.8", "start": 141, "score": 4.899999999999999e-31, "identifier": "c-SKI Smad4 binding domain", "type": "DBD", "aliEnd": 232}}], "length": 927}

TF Info Page for SKOR1 (Unknown)