H6 family homeobox 3 [Source:HGNC Symbol;Acc:HGNC:5019]
Entrez Summary
Predicted to enable DNA-binding transcription factor activity, RNA
polymerase II-specific and RNA polymerase II transcription regulatory region
sequence-specific DNA binding activity. Predicted to be involved in ear
development and regulation of transcription by RNA polymerase II. Predicted
to act upstream of or within several processes, including embryo
implantation; maternal process involved in female pregnancy; and
neuromuscular process controlling balance. Predicted to be part of chromatin.
Predicted to be active in nucleus. [provided by Alliance of Genome Resources,
Apr 2022]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF