Structure (PDB: 4A75) is with single stranded DNA.
Description
Description:
lin-28 homolog B [Source:HGNC Symbol;Acc:HGNC:32207]
Entrez Summary
The protein encoded by this gene belongs to the lin-28 family,
which is characterized by the presence of a cold-shock domain and a pair of
CCHC zinc finger domains. This gene is highly expressed in testis, fetal
liver, placenta, and in primary human tumors and cancer cell lines. It is
negatively regulated by microRNAs that target sites in the 3' UTR, and
overexpression of this gene in primary tumors is linked to the repression of
let-7 family of microRNAs and derepression of let-7 targets, which
facilitates cellular transformation. [provided by RefSeq, Jun 2012]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
x
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF