The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	TEA domain transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11714]
Entrez Summary	TBA
Ensembl ID:	ENSG00000187079
External Link:	T151688_1.02
Interpro	IPR000818; IPR016361;
Protein Domain:
Protein: ENSP00000334754	DBD: TEA	Other:
Protein: ENSP00000435393	DBD: TEA	Other:
Protein: ENSP00000435233	DBD: TEA	Other:
Protein: ENSP00000432587	DBD: TEA	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info	GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IMP - PMID:26045994 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:18579750, PMID:19324877
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
SELEX	JASPAR		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
PBM	TF_Evolution	Unpublished Data	Inferred - ENSTNIG00000008857_CONSTRUCT (75% AA Identity, PBM CONSTRUCTS)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "jagged", "end": 128, "endStyle": "jagged", "aliStart": 14, "text": "TEA", "colour": "#009900", "aliEnd": 83, "start": 5, "href": "http://pfam.xfam.org/family/PF01285.16", "type": "pfama", "display": "true", "metadata": {"end": 128, "description": "Transcriptional enhancer activators are nuclear proteins that contain a TEA/ATTSdomain, a DNA-binding region of 66-68 amino acids. The TEA/ATTS domain is found in the N-termini of certain gene regulatory proteins, such as the Simian virus 40 (SV40) enhancer factor TEF-1, yeast trans-acting factor TEC-1 (which is required for TY1 enhancer activity), and the Aspergillus abaA regulatory gene product. SV40 and retroviral enhancers, and those to which TEF-1, TEC-1 and abaA proteins bind, contain GT-IIC sites: the TEA/ATTS domain may therefore recognise and bind such sites. Secondary structure predictions suggest the presence of 3 helices, but have not confirmed the presence of the helix-turn-helix motif characteristic of many DNA-binding proteins: DNA-binding may therefore be effected by a different mechanism [PUBMED:2070413].", "database": "PfamA", "aliStart": 14, "scoreName": "E-value", "accession": "PF01285.16", "start": 5, "score": 5.4e-27, "identifier": "TEA/ATTS domain family", "type": "DBD", "aliEnd": 83}}], "length": 358}

{"regions": [{"startStyle": "jagged", "end": 140, "endStyle": "jagged", "aliStart": 28, "text": "TEA", "colour": "#009900", "aliEnd": 118, "start": 14, "href": "http://pfam.xfam.org/family/PF01285.16", "type": "pfama", "display": "true", "metadata": {"end": 140, "description": "Transcriptional enhancer activators are nuclear proteins that contain a TEA/ATTSdomain, a DNA-binding region of 66-68 amino acids. The TEA/ATTS domain is found in the N-termini of certain gene regulatory proteins, such as the Simian virus 40 (SV40) enhancer factor TEF-1, yeast trans-acting factor TEC-1 (which is required for TY1 enhancer activity), and the Aspergillus abaA regulatory gene product. SV40 and retroviral enhancers, and those to which TEF-1, TEC-1 and abaA proteins bind, contain GT-IIC sites: the TEA/ATTS domain may therefore recognise and bind such sites. Secondary structure predictions suggest the presence of 3 helices, but have not confirmed the presence of the helix-turn-helix motif characteristic of many DNA-binding proteins: DNA-binding may therefore be effected by a different mechanism [PUBMED:2070413].", "database": "PfamA", "aliStart": 28, "scoreName": "E-value", "accession": "PF01285.16", "start": 14, "score": 2.5e-27, "identifier": "TEA/ATTS domain family", "type": "DBD", "aliEnd": 118}}], "length": 427}

{"regions": [{"startStyle": "jagged", "end": 159, "endStyle": "jagged", "aliStart": 119, "text": "TEA", "colour": "#009900", "aliEnd": 159, "start": 96, "href": "http://pfam.xfam.org/family/PF01285.16", "type": "pfama", "display": "true", "metadata": {"end": 159, "description": "Transcriptional enhancer activators are nuclear proteins that contain a TEA/ATTSdomain, a DNA-binding region of 66-68 amino acids. The TEA/ATTS domain is found in the N-termini of certain gene regulatory proteins, such as the Simian virus 40 (SV40) enhancer factor TEF-1, yeast trans-acting factor TEC-1 (which is required for TY1 enhancer activity), and the Aspergillus abaA regulatory gene product. SV40 and retroviral enhancers, and those to which TEF-1, TEC-1 and abaA proteins bind, contain GT-IIC sites: the TEA/ATTS domain may therefore recognise and bind such sites. Secondary structure predictions suggest the presence of 3 helices, but have not confirmed the presence of the helix-turn-helix motif characteristic of many DNA-binding proteins: DNA-binding may therefore be effected by a different mechanism [PUBMED:2070413].", "database": "PfamA", "aliStart": 119, "scoreName": "E-value", "accession": "PF01285.16", "start": 96, "score": 1.3e-06, "identifier": "TEA/ATTS domain family", "type": "DBD", "aliEnd": 159}}], "length": 159}

TF Info Page for TEAD1 (TEA)