TF Info Page for TEAD1 (TEA)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: TEA domain transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11714]
Entrez Summary This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
Ensembl ID: ENSG00000187079
External Link: CisBP
Interpro IPR000818; IPR016361;
Protein Domain: ENSP00000334754
Protein Domain: ENSP00000435393
Protein Domain: ENSP00000435233
Protein Domain: ENSP00000432587
Protein: ENSP00000334754DBD: TEAOther:
Protein: ENSP00000435393DBD: TEAOther:
Protein: ENSP00000435233DBD: TEAOther:
Protein: ENSP00000432587DBD: TEAOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0000982
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IMP - PMID:26045994
sequence-specific DNA binding transcription factor activity
IDA - PMID:18579750, PMID:19324877
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
PBMTF_EvolutionUnpublished DataInferred - ENSTNIG00000008857_CONSTRUCT (75% AA Identity, PBM CONSTRUCTS)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution