TF Info Page for ZNF395 (C2H2 ZF(non-KRAB))
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Single C2H2 domain | Contains a single ZF (string matching on Uniprot) that is not identified using Pfam HMM thresholds. Shown to bind a short DNA sequence (GCCGGCG) by EMSA and DNase I footprinting (PMID:14625278). |
Description
| Description: | zinc finger protein 395 [Source:HGNC Symbol;Acc:HGNC:18737] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000186918 | |
| External Link: | ||
| Interpro | IPR007087; ; | |
| Protein Domain: | ||
| Protein: ENSP00000340494 | DBD: C2H2 ZF Containing Proteins | Other: DUF4772, FOXP-CC |
| Protein: ENSP00000428452 | DBD: C2H2 ZF Containing Proteins | Other: DUF4772, FOXP-CC |
| Protein: ENSP00000429640 | DBD: C2H2 ZF Containing Proteins | Other: DUF4772, FOXP-CC |
| Protein: ENSP00000429649 | DBD: C2H2 ZF Containing Proteins | Other: DUF4772 |
| Protein: ENSP00000427934 | DBD: C2H2 ZF Containing Proteins | Other: DUF4772 |
| Protein: ENSP00000429823 | DBD: C2H2 ZF Containing Proteins | Other: DUF4772 |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
No PMIDS: |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | No |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
5a, one of the source datasets predicts is as a TF |
| TF has conditional DNA-binding requirements |