TF Info Page for ZNF397 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and that it binds on centromeric regions PMID: 18369653

Description

Description: zinc finger protein 397 [Source:HGNC Symbol;Acc:HGNC:18818]
Entrez Summary This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Ensembl ID: ENSG00000186812
External Link: CisBP
Interpro IPR003309; IPR007087; IPR008916; IPR015880;
Protein Domain: ENSP00000261333
Protein Domain: ENSP00000331577
Protein Domain: ENSP00000466317
Protein Domain: ENSP00000464808
Protein Domain: ENSP00000468413
Domain:
Protein: ENSP00000261333DBD: C2H2 ZF Containing ProteinsOther: SCAN
Protein: ENSP00000331577DBD: C2H2 ZF Containing ProteinsOther: SCAN
Protein: ENSP00000466317DBD: C2H2 ZF Containing ProteinsOther: SCAN
Protein: ENSP00000464808DBD: C2H2 ZF Containing ProteinsOther: SCAN
Protein: ENSP00000468413DBD: C2H2 ZF Containing ProteinsOther: SCAN

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution