TF Info Page for ZNF75D (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE)

Description

Description: zinc finger protein 75D [Source:HGNC Symbol;Acc:HGNC:13145]
Entrez Summary This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]
Ensembl ID: ENSG00000186376
External Link: CisBP
Interpro IPR001909; IPR003309; IPR007087; IPR008916; IPR015880; ;
Protein Domain: ENSP00000359802
Protein Domain: ENSP00000359800
Domain:
Protein: ENSP00000359802DBD: C2H2 ZF Containing ProteinsOther: KRAB, SCAN
Protein: ENSP00000359800DBD: C2H2 ZF Containing ProteinsOther: KRAB, SCAN

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
RCADEImbeault2017Direct - consistent with recognition code (RCADE)
HT-SELEXYin2017Inferred - ZNF75A (86% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ZNF75A (86% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ZNF75A (86% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ZNF75A (86% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution