TF Info Page for TAL2 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 2 Obligate heteromer In vivo/Misc source No motif yielded from PBMs or HT-SELEX. Similar to TAL1, which binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA).

Description

Description: T-cell acute lymphocytic leukemia 2 [Source:HGNC Symbol;Acc:HGNC:11557]
Entrez Summary This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]
Ensembl ID: ENSG00000186051
External Link: CisBP
Interpro IPR011598; ;
Protein Domain: ENSP00000334547
Domain:
Protein: ENSP00000334547DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:8152805 11071772
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a2, orthologous lower confidence evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredInferred - TAL1 (86% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TAL1 (86% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TAL1 (86% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TAL1 (86% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TAL1 (86% AA Identity, Homo sapiens)
MiscHOMERInferred - Tal1 (86% AA Identity, Mus musculus)
MiscHOMERInferred - Tal1 (86% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - NHLH1 (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NHLH1 (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NHLH1 (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NHLH1 (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NHLH2 (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NHLH2 (58% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Nhlh2 (58% AA Identity, Mus musculus)
SELEXJASPARInferred - NHLH1 (58% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NHLH1 (58% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NHLH1 (58% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Nhlh2 (58% AA Identity, Mus musculus)
MiscHocoMocoInferred - NHLH1 (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HAND2 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HAND2 (54% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - HLH4C (54% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - HLH4C (54% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - HLH4C (54% AA Identity, Drosophila melanogaster)
MiscHocoMocoInferred - HAND1 (52% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Twist2 (51% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ATOH1 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATOH1 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH1 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH1 (50% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Atoh1 (50% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - BHLHA15 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - BHLHA15 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHA15 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHA15 (50% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Bhlha15 (50% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ATOH1 (50% AA Identity, Homo sapiens)
SELEXJASPARInferred - Atoh1 (50% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - TWIST1 (50% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TWIST1 (50% AA Identity, Homo sapiens)
MiscHOMERInferred - Atoh1 (50% AA Identity, Mus musculus)
MiscHocoMocoInferred - TWIST1 (50% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution