The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro		Contains 3 Myb DBDs

Description

Description:	MYB proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:7547]
Entrez Summary	TBA
Ensembl ID:	ENSG00000185697
External Link:
Interpro	IPR001005; IPR009057; IPR012642; IPR015395; IPR017877; IPR017930;
Protein Domain:
Protein: ENSP00000429633	DBD: Myb, Myb-Like, and SANT Domain Containing Genes	Other: Cmyb_C, LMSTEN
Protein: ENSP00000428011	DBD: Myb, Myb-Like, and SANT Domain Containing Genes	Other: Cmyb_C, LMSTEN
Protein: ENSP00000428265	DBD: Myb, Myb-Like, and SANT Domain Containing Genes	Other: Cmyb_C

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:7987850
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:7987850
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
HT-SELEX	Jolma2013		Direct
PBM	Badis09		Inferred - Mybl1 (100% AA Identity, Mus musculus)
PBM	Badis09		Inferred - Myb (87% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - MYB (87% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MYB (87% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MYB (87% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MYB (87% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MYB (87% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - Myb (87% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - MYB (87% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Myb (87% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - MYBL2 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - MYBL2 (75% AA Identity, Homo sapiens)
PBM	DREAM_contest		Inferred - Mybl2 (75% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - MYBL2 (75% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - MYBL2 (75% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - MYB_AVIMB (71% AA Identity, Avian myeloblastosis virus)
Transfac	Transfac	License required	Inferred - MYB_AVIMB (71% AA Identity, Avian myeloblastosis virus)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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{"regions": [{"startStyle": "curved", "end": 81, "endStyle": "curved", "aliStart": 35, "text": "Myb", "colour": "#228B22", "aliEnd": 81, "start": 35, "href": "http://pfam.xfam.org/family/PF00249.29", "type": "pfama", "display": "true", "metadata": {"end": 81, "description": "This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.", "database": "PfamA", "aliStart": 35, "scoreName": "E-value", "accession": "PF00249.29", "start": 35, "score": 1.6999999999999995e-55, "identifier": "Myb-like DNA-binding domain", "type": "DBD", "aliEnd": 81}}, {"startStyle": "curved", "end": 133, "endStyle": "curved", "aliStart": 87, "text": "Myb", "colour": "#228B22", "aliEnd": 133, "start": 87, "href": "http://pfam.xfam.org/family/PF00249.29", "type": "pfama", "display": "true", "metadata": {"end": 133, "description": "This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.", "database": "PfamA", "aliStart": 87, "scoreName": "E-value", "accession": "PF00249.29", "start": 87, "score": 1.6999999999999995e-55, "identifier": "Myb-like DNA-binding domain", "type": "DBD", "aliEnd": 133}}, {"startStyle": "curved", "end": 184, "endStyle": "curved", "aliStart": 139, "text": "Myb", "colour": "#228B22", "aliEnd": 182, "start": 139, "href": "http://pfam.xfam.org/family/PF00249.29", "type": "pfama", "display": "true", "metadata": {"end": 184, "description": "This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.", "database": "PfamA", "aliStart": 139, "scoreName": "E-value", "accession": "PF00249.29", "start": 139, "score": 1.6999999999999995e-55, "identifier": "Myb-like DNA-binding domain", "type": "DBD", "aliEnd": 182}}, {"startStyle": "straight", "end": 649, "endStyle": "straight", "aliStart": 486, "text": "Cmyb_C", "colour": "#9999ff", "aliEnd": 645, "start": 486, "href": "http://pfam.xfam.org/family/PF09316.8", "type": "pfama", "display": "true", "metadata": {"end": 649, "description": "Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis [1].", "database": "PfamA", "aliStart": 486, "scoreName": "E-value", "accession": "PF09316.8", "start": 486, "score": 9.599999999999998e-80, "identifier": "C-myb, C-terminal", "type": "DBD", "aliEnd": 645}}, {"startStyle": "straight", "end": 286, "endStyle": "straight", "aliStart": 241, "text": "LMSTEN", "colour": "#9999ff", "aliEnd": 286, "start": 240, "href": "http://pfam.xfam.org/family/PF07988.10", "type": "pfama", "display": "true", "metadata": {"end": 286, "description": "This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.", "database": "PfamA", "aliStart": 241, "scoreName": "E-value", "accession": "PF07988.10", "start": 240, "score": 1.1e-28, "identifier": "LMSTEN motif", "type": "DBD", "aliEnd": 286}}], "length": 693}

TF Info Page for MYBL1 (Myb/SANT)