TF Info Page for IRF7 (IRF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122]
Entrez Summary IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000185507
External Link: CisBP
Interpro IPR001346; IPR008984; IPR019471; IPR019817;
Protein Domain: ENSP00000331803
Protein Domain: ENSP00000380697
Protein Domain: ENSP00000380700
Protein Domain: ENSP00000380704
Domain:
Protein: ENSP00000331803DBD: Interferon regulatory factor (IRF)Other: IRF-3
Protein: ENSP00000380697DBD: Interferon regulatory factor (IRF)Other: IRF-3
Protein: ENSP00000380700DBD: Interferon regulatory factor (IRF)Other: IRF-3
Protein: ENSP00000380704DBD: Interferon regulatory factor (IRF)Other: IRF-3

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:9786932
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000982
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:17404045
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
HT-SELEXYin2017Inferred - IRF7 (100% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - IRF7 (100% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ENSG00000276561 (100% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ENSG00000276561 (100% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ENSG00000276561 (100% AA Identity, Homo sapiens)
MiscHocoMocoInferred - IRF7 (100% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution